性别、细胞与哮喘。
Sex, Cells, and Asthma.
机构信息
Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, MN.
Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Tampa.
出版信息
Mayo Clin Proc. 2021 Jul;96(7):1955-1969. doi: 10.1016/j.mayocp.2020.12.007.
Abstract
There are marked sex differences in asthma prevalence and severity. Sex hormones play a central role in these sex biases and directly interact with multiple key cells involved in the pathogenesis of asthma. Here we review the known effects of estrogen, progesterone, and testosterone on airway epithelial cells, airway smooth muscle cells, the mononuclear phagocyte system, innate lymphoid cells, eosinophils, mast cells, T cells, and B cells, all in the context of asthma. Furthermore, we explore unresolved clinical questions, such as the role of sex hormones in the link between asthma and obesity.
摘要
哮喘的患病率和严重程度存在明显的性别差异。性激素在这些性别差异中起着核心作用，并与哮喘发病机制中涉及的多种关键细胞直接相互作用。在这里，我们回顾了雌激素、孕激素和睾酮对气道上皮细胞、气道平滑肌细胞、单核吞噬细胞系统、固有淋巴细胞、嗜酸性粒细胞、肥大细胞、T 细胞和 B 细胞的已知影响，所有这些都是在哮喘的背景下进行的。此外，我们还探讨了未解决的临床问题，例如性激素在哮喘与肥胖之间的联系中的作用。
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