Damage to DNA concurrent with lipid peroxidation in rat liver slices.
作者信息
Fraga C G, Tappel A L
机构信息
Department of Food Science and Technology, University of California, Davis, 95616.
出版信息
Biochem J. 1988 Jun 15;252(3):893-6. doi: 10.1042/bj2520893.
Abstract
Lipid peroxidation and DNA damage were evaluated in liver slices incubated for 2 h at 37 degrees C with 1 mM-t-butyl hydroperoxide (t-BOOH), 1 mM-BrCCl3 or 50 microM-ferrous iron. t-BOOH induced the greatest amount of damage to DNA and increased the production of thiobarbituric acid-reactive substances (TBARS). Both phenomena depended on the incubation time. Ferrous iron induced both DNA damage and TBARS production, and BrCCl3 did not induce significant DNA damage and was the weakest TBARS inducer. Butylated hydroxytoluene at 1 mM inhibited both DNA damage and TBARS production. DNA damage and lipid peroxidation in liver slices were correlated, indicating that these events were concurrent.
摘要
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本文引用的文献
1
Rapid isolation of high molecular weight plant DNA.
Nucleic Acids Res. 1980 Oct 10;8(19):4321-5. doi: 10.1093/nar/8.19.4321.
2
The damaging action of hydrogen peroxide on DNA of human fibroblasts is mediated by a non-dialyzable compound.
Biochim Biophys Acta. 1980 Jun 27;608(1):167-73. doi: 10.1016/0005-2787(80)90144-6.
3
Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron.
Biochem J. 1984 Feb 15;218(1):273-5. doi: 10.1042/bj2180273.
4
Correlation between cytotoxic effect of hydrogen peroxide and the yield of DNA strand breaks in cells of different species.
Biochim Biophys Acta. 1984 Apr 5;781(3):234-8. doi: 10.1016/0167-4781(84)90088-5.
5
Effects of dietary polyunsaturated fats and vitamin E on aging and peroxidative damage to DNA.
Arch Biochem Biophys. 1984 Sep;233(2):408-16. doi: 10.1016/0003-9861(84)90462-4.
6
Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.
Science. 1983 Sep 23;221(4617):1256-64. doi: 10.1126/science.6351251.
7
Ethidium binding assay for reactive oxygen species generated from reductively activated adriamycin (doxorubicin).
Methods Enzymol. 1984;105:532-9. doi: 10.1016/s0076-6879(84)05073-4.
8
In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction.
Biochim Biophys Acta. 1984 Feb 24;781(1-2):56-63. doi: 10.1016/0167-4781(84)90123-4.
9
Protection of iron-catalysed the radical damage to DNA and lipids by copper (II) bleomycin.
Biochem Biophys Res Commun. 1981 Apr 30;99(4):1354-60. doi: 10.1016/0006-291x(81)90768-3.
10
Native and denatured DNA, cross-linked and palindromic DNA and circular covalently-closed DNA analysed by a sensitive fluorometric procedure.
Biochem Biophys Res Commun. 1974 Nov 27;61(2):396-403. doi: 10.1016/0006-291x(74)90970-x.
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