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嗜冷菌:希望之旅。

Psychrophiles: A journey of hope.

机构信息

Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Belagavi 590 010, India.

出版信息

J Biosci. 2021;46.

PMID:34219740
Abstract

Psychrophiles are organisms living in extremely cold conditions within the temperature range of -20°C to +10°C. These organisms survive in harsh environment by modulating their genetic make-up to thrive in extremely cold conditions. These cold-adaptations are closely associated with changes in the life forms, gene expression, and proteins, enzymes, lipids, etc. This review gives a brief description of the life and genetic adaptations of psychrophiles for their survival in extreme conditions as well as the bioactive compounds that are potential antimicrobials.

摘要

嗜冷菌是指在-20°C 到+10°C 的温度范围内生活在极端寒冷条件下的生物体。这些生物体通过调节其基因组成来适应极端寒冷的条件,从而在恶劣环境中生存。这些低温适应与生命形式、基因表达和蛋白质、酶、脂质等的变化密切相关。本综述简要描述了嗜冷菌的生活和遗传适应,以使其在极端条件下生存,以及具有潜在抗菌活性的生物活性化合物。

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本文引用的文献

1
Antibiotics from Marine Bacteria.海洋细菌来源的抗生素。
Biochemistry (Mosc). 2020 Nov;85(11):1362-1373. doi: 10.1134/S0006297920110073.
2
Novel Psychrophiles and Exopolymers from Permafrost Thaw Lake Sediments.来自永久冻土融化湖沉积物的新型嗜冷菌和胞外聚合物。
Microorganisms. 2020 Aug 22;8(9):1282. doi: 10.3390/microorganisms8091282.
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CRISPR-Cas system: a potential alternative tool to cope antibiotic resistance.CRISPR-Cas 系统:应对抗生素耐药性的潜在替代工具。
PLoS One. 2025 Mar 6;20(3):e0318459. doi: 10.1371/journal.pone.0318459. eCollection 2025.
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From freezing to functioning: cellular strategies of cold-adapted bacteria for surviving in extreme environments.从冷冻到运转:适应寒冷的细菌在极端环境中生存的细胞策略
Arch Microbiol. 2024 Jun 28;206(7):329. doi: 10.1007/s00203-024-04058-5.
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Extremophiles: the species that evolve and survive under hostile conditions.极端微生物:在恶劣条件下进化并生存的物种。
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Modern Trends in Natural Antibiotic Discovery.天然抗生素发现的现代趋势
Life (Basel). 2023 Apr 23;13(5):1073. doi: 10.3390/life13051073.
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Some Clues about Enzymes from Psychrophilic Microorganisms.来自嗜冷微生物的一些关于酶的线索。
Microorganisms. 2022 Jun 6;10(6):1161. doi: 10.3390/microorganisms10061161.
8
From Protein Design to the Energy Landscape of a Cold Unfolding Protein.从蛋白质设计到冷变性蛋白质的能量景观。
J Phys Chem B. 2022 Feb 17;126(6):1212-1231. doi: 10.1021/acs.jpcb.1c10750. Epub 2022 Feb 7.
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Genomic Insights of Isolated From Ice Core Reveal Genome Dynamics for Adaptation in Glacier.从冰芯分离出的基因组见解揭示了冰川适应中的基因组动态。
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5
Horizontal gene transfer and silver nanoparticles production in a new Marinomonas strain isolated from the Antarctic psychrophilic ciliate Euplotes focardii.从南极嗜冷纤毛虫 Euplotes focardii 中分离到的一株新 Marinomonas 菌株中的水平基因转移和银纳米粒子的产生。
Sci Rep. 2020 Jun 23;10(1):10218. doi: 10.1038/s41598-020-66878-x.
6
How CRISPR-Cas System Could Be Used to Combat Antimicrobial Resistance.CRISPR-Cas系统如何用于对抗抗菌药物耐药性。
Infect Drug Resist. 2020 Apr 20;13:1111-1121. doi: 10.2147/IDR.S247271. eCollection 2020.
7
DNA Methylation Changes Induced by Cold in Psychrophilic and Psychrotolerant Yeast Species.嗜冷和耐冷酵母物种中低温诱导的DNA甲基化变化
Microorganisms. 2020 Feb 20;8(2):296. doi: 10.3390/microorganisms8020296.
8
Protein expression in the obligate hydrocarbon-degrading psychrophile Oleispira antarctica RB-8 during alkane degradation and cold tolerance.在烷烃降解和耐冷过程中,专性烃降解嗜冷菌 Oleispira antarctica RB-8 中的蛋白质表达。
Environ Microbiol. 2020 May;22(5):1870-1883. doi: 10.1111/1462-2920.14956. Epub 2020 Feb 28.
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Synthesis of Bioactive Silver Nanoparticles by a Strain Associated with the Antarctic Psychrophilic Protozoon .南极嗜冷原生动物相关菌株合成生物活性银纳米粒子
Mar Drugs. 2020 Jan 3;18(1):38. doi: 10.3390/md18010038.
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sp. nov., a novel psychrophilic bacterium isolated from Arctic soil.sp. nov.,一种从北极土壤中分离到的新型嗜冷细菌。
Int J Syst Evol Microbiol. 2020 Jan;70(1):44-50. doi: 10.1099/ijsem.0.003707.