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口罩材料的石墨烯纳米片和氧化石墨烯功能化可抑制捕获的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的传染性。

Graphene nanoplatelet and graphene oxide functionalization of face mask materials inhibits infectivity of trapped SARS-CoV-2.

作者信息

De Maio Flavio, Palmieri Valentina, Babini Gabriele, Augello Alberto, Palucci Ivana, Perini Giordano, Salustri Alessandro, Spilman Patricia, De Spirito Marco, Sanguinetti Maurizio, Delogu Giovanni, Rizzi Laura Giorgia, Cesareo Giulio, Soon-Shiong Patrick, Sali Michela, Papi Massimiliano

机构信息

Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" IRCSS, Largo A. Gemelli, 8 00168 Rome, Italy.

Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie - Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.

出版信息

iScience. 2021 Jul 23;24(7):102788. doi: 10.1016/j.isci.2021.102788. Epub 2021 Jun 25.

DOI:10.1016/j.isci.2021.102788
PMID:34222841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8233064/
Abstract

Recent advancements in bidimensional nanoparticles production such as graphene (G) and graphene oxide (GO) have the potential to meet the need for highly functional personal protective equipment (PPE) against SARS-CoV-2 infection. The ability of G and GO to interact with microorganisms provides an opportunity to develop engineered textiles for use in PPE and limit the spread of COVID-19. PPE in current use in high-risk settings for COVID transmission provides only a physical barrier that decreases infection likelihood and does not inactivate the virus. Here, we show that virus pre-incubation with soluble GO inhibits SARS-CoV-2 infection of VERO cells. Furthermore, when G/GO-functionalized polyurethane or cotton was in contact SARS-CoV-2, the infectivity of the fabric was nearly completely inhibited. The findings presented here constitute an important innovative nanomaterial-based strategy to significantly increase PPE efficacy in protection against the SARS-CoV-2 virus that may implement water filtration, air purification, and diagnostics methods.

摘要

二维纳米颗粒（如石墨烯（G）和氧化石墨烯（GO））生产方面的最新进展有潜力满足对针对SARS-CoV-2感染的高功能个人防护装备（PPE）的需求。G和GO与微生物相互作用的能力为开发用于PPE的工程纺织品以及限制COVID-19的传播提供了机会。当前在COVID传播高风险环境中使用的PPE仅提供物理屏障，可降低感染可能性，但不能使病毒失活。在此，我们表明，用可溶性GO预孵育病毒可抑制SARS-CoV-2对VERO细胞的感染。此外，当G/GO功能化的聚氨酯或棉花与SARS-CoV-2接触时，织物的传染性几乎被完全抑制。此处呈现的研究结果构成了一种重要的基于创新纳米材料的策略，可显著提高PPE在预防SARS-CoV-2病毒方面的功效，这可能会应用水过滤、空气净化和诊断方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/9e4b42b2aeeb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/41fb7d631dae/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/49e84a51b063/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/2c845a1fd264/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/f8c2d9d8c48a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/605d04af32b9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/9e4b42b2aeeb/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/41fb7d631dae/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/49e84a51b063/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/2c845a1fd264/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/f8c2d9d8c48a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/605d04af32b9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d257/8271168/9e4b42b2aeeb/gr5.jpg

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