HPV 病毒 DNA 在选择堕胎的女性胎盘中的证据。
Evidence for HPV DNA in the placenta of women who resorted to elective abortion.
机构信息
Department of General Surgery and Medical Surgery Specialties, Gynecological Clinic, University of Catania, Catania, Italy.
出版信息
BMC Pregnancy Childbirth. 2021 Jul 6;21(1):485. doi: 10.1186/s12884-021-03937-9.
BACKGROUND
It is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth. In clinical cases of placental villi positive for HPV DNA reported by other authors, contamination is suspected in the act of crossing the cervical canal. We analyzed placental samples of women who resorted to elective abortion obtained by hysterosuction of ovular material, bypassing any contact with the cervical canal and vagina.
METHODS
We studied the chorionic villi of the placenta of 64 women who resorted to voluntary termination of pregnancy, in the first trimester. To avoid contamination of the villi by the cervical canal, we analyzed placental samples obtained by hysterosuction of ovular material, bypassing any contact with the cervical canal and vagina. All samples of chorionic villi were manually selected from the aborted material and subjected to research for HPV DNA.
RESULTS
HPV DNA was detected in 10 out of 60 women (16.6%). The HPV DNA identified in the placenta belonged to genotypes 6, 16, 35, 53, and 90.
CONCLUSION
The study shows that papillomavirus DNA can infect the placenta and that placenta HPV infection can occur as early as the first trimester of pregnancy.
背景
人们认为 HPV 感染可导致胎盘滋养层细胞死亡，并导致流产或早产。在其他作者报道的胎盘绒毛 HPV DNA 阳性的临床病例中，怀疑在穿过宫颈管时发生了污染。我们分析了 64 名因胚胎物质抽吸而选择人工流产的妇女的胎盘样本，该方法绕过了与宫颈管和阴道的任何接触。
方法
我们研究了 64 名因早孕而选择人工流产的妇女的胎盘绒毛。为了避免绒毛被宫颈管污染，我们分析了通过抽吸胚胎物质获得的胎盘样本，该方法绕过了与宫颈管和阴道的任何接触。所有绒毛组织样本均从流产物质中手动选择，并进行 HPV DNA 研究。
结果
在 60 名妇女中有 10 名（16.6%）检测到 HPV DNA。在胎盘内鉴定出的 HPV DNA 属于基因型 6、16、35、53 和 90。
结论
该研究表明，乳头瘤病毒 DNA 可感染胎盘，胎盘 HPV 感染可早在妊娠早期发生。
Zotero 插件