Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O.Box: 15875-4413, Tehran, Iran.
Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O.Box: 15875-4413, Tehran, Iran.
Tissue Cell. 2021 Oct;72:101588. doi: 10.1016/j.tice.2021.101588. Epub 2021 Jul 2.
Bone tissue is a highly vascularized and dynamic tissue that continues to remodel throughout the life cycle of a person. Only a few researches are done on usage of zeolitic imidazolate framework-8 (ZIF-8) in the bone tissue engineering area. Hence, this review is focused on the application of the ZIF-8 in bone tissue engineering. This work includes an explanation of metal-organic frameworks (MOFs) and ZIF-8 including synthesis methods as well as biocompatibility and biomedical applications of ZIF-8. In fact, a literature review is provided on previous applications of ZIF-8 in bone tissue engineering. Also, the investigations related to employing ZIF-8 in bone scaffolds and drug delivery systems for the bone tissues are discussed, and future perspectives are also emphasized.
骨组织是一种高度血管化和动态的组织，在人的生命周期中不断进行重塑。只有少数研究是关于沸石咪唑酯骨架-8（ZIF-8）在骨组织工程领域的应用。因此，本综述重点介绍了 ZIF-8 在骨组织工程中的应用。这项工作包括对金属有机骨架（MOFs）和 ZIF-8 的解释，包括合成方法以及 ZIF-8 的生物相容性和生物医学应用。事实上，提供了关于 ZIF-8 在骨组织工程中的先前应用的文献综述。此外，还讨论了将 ZIF-8 应用于骨支架和药物输送系统以用于骨组织的研究，并强调了未来的展望。
