Zhang Yingyi, Ren Libin, Ren Min, Yang Hua, Li Kunmeng, Cong Hongliang, Guo Zhigang
Department of Cardiology, Tianjin Chest Hospital, Tianjin, 300222, People's Republic of China.
Tianjin Cardiovascular Institute, Tianjin, 300222, People's Republic of China.
Risk Manag Healthc Policy. 2021 Jul 2;14:2803-2810. doi: 10.2147/RMHP.S316484. eCollection 2021.
This study aims to investigate the correlation between triglyceride-glucose index (TyG) and the risk of cardiovascular disease (CVD).
A total of 102,061 permanent residents of Tianjin, China, aged 35-75 years were surveyed. A questionnaire, physical examination, and blood tests for biochemical markers were conducted for all subjects. The risk of CVD was judged based on the results, identifying the population with a high risk of CVD. TyG was calculated for all subjects who were then grouped into TyG quartiles. The correlation between TyG and the detection rate of subjects with a high risk of CVD was analyzed using the chi-square test and Pearson's correlation analysis. The cut-off points and the magnitude of the predictive effect of TyG in determining a high risk of CVD were identified by calculating the TyG through analysis of the receiver operator characteristic (ROC) curve.
The surveyed population consisted of 39,598 males (38.8%) and 62,463 females (61.2%). The average age was 55.84 ± 10.27 years. A statistically significant difference in the incidence of a high CVD risk between subjects in the four groups divided by the TyG levels was identified ( < 0.01). Pearson's correlation analysis showed that TyG was correlated with all risk factors for CVD ( < 0.01). The maximum Youden's J statistic for determining the high risk of CVD was found at a TyG of 9.04 (specificity 0.575, sensitivity 0.754). The area under the ROC curve was 0.780 (confidence interval [CI]: 0.777, 0.783, < 0.01).
TyG index is closely related to the aggregation of cardiovascular risk factors and is correlated with the judgment results of the screening population's high risk of CVD, suggesting that more attention should be paid to the identification and control of multiple risk factors in the population with significantly elevated TyG.
本研究旨在探讨甘油三酯-葡萄糖指数（TyG）与心血管疾病（CVD）风险之间的相关性。
对中国天津市102,061名年龄在35 - 75岁的常住居民进行调查。对所有受试者进行问卷调查、体格检查及血液生化指标检测。根据结果判断CVD风险，确定CVD高风险人群。计算所有受试者的TyG，并将其分为TyG四分位数组。采用卡方检验和Pearson相关分析分析TyG与CVD高风险受试者检出率之间的相关性。通过分析受试者工作特征（ROC）曲线计算TyG，确定TyG在判定CVD高风险时的截断点及预测效果大小。
调查人群包括39,598名男性（38.8%）和62,463名女性（61.2%）。平均年龄为55.84±10.27岁。按TyG水平划分的四组受试者中，CVD高风险发生率存在统计学显著差异（<0.01）。Pearson相关分析表明，TyG与CVD的所有风险因素相关（<0.01）。确定CVD高风险时最大约登指数（Youden's J statistic）出现在TyG为9.04时（特异性0.575，敏感性0.754）。ROC曲线下面积为0.780（置信区间[CI]：0.777, 0.783，<0.01）。
TyG指数与心血管危险因素聚集密切相关，与筛查人群CVD高风险的判断结果相关，提示应更加关注TyG显著升高人群中多种危险因素的识别与控制。
