记忆组织的维度和机制。
Dimensions and mechanisms of memory organization.
机构信息
Departments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Departments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Neuron. 2021 Sep 1;109(17):2649-2662. doi: 10.1016/j.neuron.2021.06.014. Epub 2021 Jul 8.
Memory formation is dynamic in nature, and acquisition of new information is often influenced by previous experiences. Memories sharing certain attributes are known to interact so that retrieval of one increases the likelihood of retrieving the other, raising the possibility that related memories are organized into associative mnemonic structures of interconnected representations. Although the formation and retrieval of single memories have been studied extensively, very little is known about the brain mechanisms that organize and link related memories. Here we review studies that suggest the existence of mnemonic structures in humans and animal models. These studies suggest three main dimensions of experience that can serve to organize related memories: time, space, and perceptual/conceptual similarities. We propose potential molecular, cellular, and systems mechanisms that might support organization of memories according to these dimensions.
记忆的形成本质上是动态的，新信息的获取通常会受到先前经验的影响。人们知道，具有某些共同属性的记忆会相互作用，因此检索一个记忆会增加检索另一个记忆的可能性，这就提出了一个可能性，即相关的记忆被组织成相互关联的表示的联想记忆结构。尽管已经对单个记忆的形成和检索进行了广泛的研究，但对于将相关记忆组织和联系起来的大脑机制却知之甚少。在这里，我们回顾了一些表明人类和动物模型中存在记忆结构的研究。这些研究表明，有三个主要的经验维度可以用来组织相关的记忆：时间、空间和知觉/概念相似性。我们提出了潜在的分子、细胞和系统机制，这些机制可能支持根据这些维度来组织记忆。
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