Gulati Karan, Scimeca Jean-Claude, Ivanovski Sašo, Verron Elise
The University of Queensland, School of Dentistry, Herston, QLD 4006, Australia.
Université Côte d'Azur, CNRS, Inserm, iBV, France.
Drug Discov Today. 2021 Nov;26(11):2734-2742. doi: 10.1016/j.drudis.2021.07.004. Epub 2021 Jul 9.
Titanium-based orthopaedic/dental implants modified with various metal-doping strategies can enhance local therapy and bioactivity. Intentional or unintentional (because of loading and wear) release of metal ions/nanoparticles (NPs) from metal-doped implants can be therapeutic or cause adverse local tissue reactions, compromising long-term survival. Strategies to incorporate metals into implants, such as superficial or deep loading inside nano-engineered surfaces, including nanotubes, and the physiochemical characteristics of the released species significantly influence both their therapeutic and cytotoxic potential. In this review, we compare and contrast this 'double-edged sword' to arrive at an improved understanding of metal-doped implants to enable controlled therapy while minimising cytotoxicity concerns.
采用各种金属掺杂策略改性的钛基骨科/牙科植入物可增强局部治疗效果和生物活性。金属掺杂植入物有意或无意（由于负载和磨损）释放的金属离子/纳米颗粒可能具有治疗作用，也可能引起局部组织不良反应，从而影响长期存活率。将金属纳入植入物的策略，如在纳米工程表面（包括纳米管）进行表面或深度负载，以及释放物质的物理化学特性，都会显著影响其治疗潜力和细胞毒性。在本综述中，我们对这把“双刃剑”进行比较和对比，以更好地理解金属掺杂植入物，从而实现可控治疗，同时将细胞毒性问题降至最低。
