Szydlak Renata
Department of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-034, Poland.
World J Stem Cells. 2021 Jun 26;13(6):619-631. doi: 10.4252/wjsc.v13.i6.619.
Mesenchymal stem cells (MSCs) are a population of primary and non-specialized cells, which can be isolated from various tissues. Currently, MSCs are key players in cellular therapy and regenerative medicine. However, the possibility of using MSCs in the treatment of many diseases needs to be preceded, though, by in-depth analysis of their properties, especially by determining the mechanism of tissue homing as well as the mechanism, due to which cells contribute to tissue regeneration. This review is intended to present information on recent findings regarding the mechanism of recruitment and tissue homing by MSCs and discuss current hypotheses for how MSCs can reach target tissues.
间充质干细胞（MSCs）是一群原始的、未分化的细胞，可从多种组织中分离得到。目前，MSCs是细胞治疗和再生医学的关键参与者。然而，在将MSCs用于治疗多种疾病之前，需要对其特性进行深入分析，尤其是确定其组织归巢机制以及细胞促进组织再生的机制。本综述旨在介绍有关MSCs募集和组织归巢机制的最新研究结果，并讨论目前关于MSCs如何到达靶组织的假说。
