染色体外DNA元件在肿瘤进展中的作用。
The contributions of extrachromosomal DNA elements in neoplasm progression.
作者信息
Hong Jiawei, Zheng Shusen, Jiang Donghai
机构信息
Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou 310000, China.
NHFPC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310000, China.
出版信息
Am J Cancer Res. 2021 Jun 15;11(6):2417-2429. eCollection 2021.
Abstract
Extrachromosomal DNA (ecDNA) is a small, circular structure of DNA found outside chromosomes, in the cytoplasm and outside cells. Since the discovery of ecDNA in 1964, more studies have verified the significant prospect and application potential of its use in oncology. The presence of ecDNA is associated with a series of tumor activities such as the increasing or decreasing of oncogene copies, carcinogenic transmission, and activation of related signaling pathways. This review focuses on discussing the structure of ecDNA and its relevance in carcinogenesis, angiogenesis, drug resistance and metastasis.
摘要
染色体外DNA（ecDNA）是一种在染色体之外发现的小型环状DNA结构，存在于细胞质和细胞外。自1964年ecDNA被发现以来，越来越多的研究证实了其在肿瘤学中应用的巨大前景和潜力。ecDNA的存在与一系列肿瘤活动相关，如癌基因拷贝数的增加或减少、致癌传递以及相关信号通路的激活。本综述着重讨论ecDNA的结构及其在致癌、血管生成、耐药性和转移中的相关性。
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