Yang Tiqun, Long Tianxin, Du Tailai, Chen Yili, Dong Yugang, Huang Zhan-Peng
Department of Cardiology, Center for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
National Health Commission (NHC) Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China.
Front Cardiovasc Med. 2021 Jun 25;8:702586. doi: 10.3389/fcvm.2021.702586. eCollection 2021.
Cardiac remodeling occurs after the heart is exposed to stress, which is manifested by pathological processes such as cardiomyocyte hypertrophy and apoptosis, dendritic cells activation and cytokine secretion, proliferation and activation of fibroblasts, and finally leads to heart failure. Circular RNAs (circRNAs) are recently recognized as a specific type of non-coding RNAs that are expressed in different species, in different stages of development, and in different pathological conditions. Growing evidences have implicated that circRNAs play important regulatory roles in the pathogenesis of a variety of cardiovascular diseases. In this review, we summarize the biological origin, characteristics, functional classification of circRNAs and their regulatory functions in cardiomyocytes, endothelial cells, fibroblasts, immune cells, and exosomes in the pathogenesis of cardiac remodeling.
心脏在受到应激后会发生心脏重塑，其表现为心肌细胞肥大和凋亡、树突状细胞激活和细胞因子分泌、成纤维细胞增殖和激活等病理过程，最终导致心力衰竭。环状RNA（circRNAs）是最近被认可的一种特殊类型的非编码RNA，在不同物种、不同发育阶段和不同病理条件下均有表达。越来越多的证据表明，circRNAs在多种心血管疾病的发病机制中发挥着重要的调节作用。在这篇综述中，我们总结了circRNAs的生物学起源、特征、功能分类及其在心脏重塑发病机制中对心肌细胞、内皮细胞、成纤维细胞、免疫细胞和外泌体的调节功能。
