Özbek Memmet, Hitit Mustafa, Kaya Abdullah, Jousan Frank Dean, Memili Erdogan
Department of Histology and Embryology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey.
Department of Genetics, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu, Turkey.
Front Vet Sci. 2021 Jun 22;8:610888. doi: 10.3389/fvets.2021.610888. eCollection 2021.
Bull fertility is an important economic trait in sustainable cattle production, as infertile or subfertile bulls give rise to large economic losses. Current methods to assess bull fertility are tedious and not totally accurate. The massive collection of functional data analyses, including genomics, proteomics, metabolomics, transcriptomics, and epigenomics, helps researchers generate extensive knowledge to better understand the unraveling physiological mechanisms underlying subpar male fertility. This review focuses on the sperm phenomes of the functional genome and epigenome that are associated with bull fertility. Findings from multiple sources were integrated to generate new knowledge that is transferable to applied andrology. Diverse methods encompassing analyses of molecular and cellular dynamics in the fertility-associated molecules and conventional sperm parameters can be considered an effective approach to determine bull fertility for efficient and sustainable cattle production. In addition to gene expression information, we also provide methodological information, which is important for the rigor and reliability of the studies. Fertility is a complex trait influenced by several factors and has low heritability, although heritability of scrotal circumference is high and that it is a known fertility maker. There is a need for new knowledge on the expression levels and functions of sperm RNA, proteins, and metabolites. The new knowledge can shed light on additional fertility markers that can be used in combination with scrotal circumference to predict the fertility of breeding bulls. This review provides a comprehensive review of sperm functional characteristics or phenotypes associated with bull fertility.
公牛繁殖力是可持续养牛生产中的一个重要经济性状，因为不育或繁殖力低下的公牛会造成巨大的经济损失。目前评估公牛繁殖力的方法既繁琐又不完全准确。对包括基因组学、蛋白质组学、代谢组学、转录组学和表观基因组学在内的大量功能数据分析，有助于研究人员积累丰富的知识，从而更好地理解雄性繁殖力低下背后尚未阐明的生理机制。本综述聚焦于与公牛繁殖力相关的功能基因组和表观基因组的精子表型组。整合来自多个来源的研究结果，以产生可应用于临床男科学的新知识。涵盖对与繁殖力相关分子的分子和细胞动力学分析以及传统精子参数的多种方法，可被视为确定公牛繁殖力以实现高效和可持续养牛生产的有效途径。除了基因表达信息外，我们还提供方法学信息，这对研究的严谨性和可靠性很重要。繁殖力是一个受多种因素影响的复杂性状，遗传力较低，尽管阴囊周长的遗传力较高，且它是一个已知的繁殖力指标。需要有关精子RNA、蛋白质和代谢物表达水平及功能的新知识。这些新知识可以揭示其他繁殖力标记，可与阴囊周长结合使用以预测种公牛的繁殖力。本综述全面回顾了与公牛繁殖力相关的精子功能特征或表型。
