Bakx Nienke, Bluemink Hanneke, Hagelaar Els, van der Leer Jorien, van der Sangen Maurice, Theuws Jacqueline, Hurkmans Coen
Catharina Ziekenhuis, Department of Radiation Oncology, Eindhoven, the Netherlands.
Phys Imaging Radiat Oncol. 2021 Apr 28;18:48-50. doi: 10.1016/j.phro.2021.04.002. eCollection 2021 Apr.
During breast cancer radiotherapy, sparing of healthy tissue is desired. The effect of automatic beam angle optimization and generic dose fall-off objectives on dose and normal tissue complication probabilities was studied. In all patients, dose to lungs and heart showed a mean reduction of 0.4 Gy (range 0.1-1.3 Gy) and 0.2 Gy (range -0.2-0.7 Gy), respectively. These lower doses led to a statistically significant lower cumulative cardiac and lung cancer mortality risk. For smoking patients 40-45 years of age who continue to smoke, it would lead to a reduction from 3.2% ± 0.7% to 2.7% ± 0.6% (p < 0.001).
在乳腺癌放疗期间，希望能够保护健康组织。研究了自动射束角度优化和一般剂量下降目标对剂量及正常组织并发症概率的影响。在所有患者中，肺部和心脏的剂量平均分别降低了0.4 Gy（范围为0.1 - 1.3 Gy）和0.2 Gy（范围为 - 0.2 - 0.7 Gy）。这些较低的剂量导致累积心脏和肺癌死亡风险在统计学上显著降低。对于40 - 45岁且继续吸烟的患者，这将导致风险从3.2% ± 0.7%降至2.7% ± 0.6%（p < 0.001）。
