Wren C, Sullivan I, Bull C, Deanfield J
Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne.
Br Heart J. 1987 Dec;58(6):608-12. doi: 10.1136/hrt.58.6.608.
Percutaneous balloon dilatation of severe aortic valve stenosis was attempted in thirteen patients (seven neonates and six infants). In two the valve could not be crossed and both died during subsequent operation. Two patients died during manipulation of the balloon catheter. No significant benefit was obtained in another patient who later died during operation. Balloon dilatation was successful in the remaining eight patients, reducing the aortic valve pressure gradient from a mean of 63 mmHg (95% confidence interval 38 to 88 mmHg) to a mean of 23 mmHg (95% confidence interval 7 to 39 mmHg). Two of these patients subsequently died from heart failure related to other cardiac lesions. The six survivors have done well. At follow up the maximum Doppler velocities in the ascending aorta ranged from 1.9 to 4.0 m/s after 2-23 months, but despite this evidence of an increasing valve gradient there has been lasting clinical improvement.
对13例患者（7例新生儿和6例婴儿）尝试进行经皮球囊扩张治疗严重主动脉瓣狭窄。其中2例瓣膜未能穿过，均在随后的手术中死亡。2例患者在球囊导管操作过程中死亡。另有1例患者在后来的手术中死亡，未获得明显益处。其余8例患者球囊扩张成功，主动脉瓣压力阶差从平均63 mmHg（95%置信区间38至88 mmHg）降至平均23 mmHg（95%置信区间7至39 mmHg）。其中2例患者随后死于与其他心脏病变相关的心力衰竭。6例幸存者情况良好。随访时，升主动脉最大多普勒速度在2至23个月后为1.9至4.0 m/s，尽管有证据表明瓣膜压力阶差增加，但临床仍有持续改善。
