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先天性主动脉瓣狭窄球囊瓣膜成形术和外科瓣膜切开术的当代结果。

Contemporary results of balloon valvuloplasty and surgical valvotomy for congenital aortic stenosis.

作者信息

Gatzoulis M A, Rigby M L, Shinebourne E A, Redington A N

机构信息

Department of Paediatric Cardiology, Royal Brompton Hospital/National Heart and Lung Institute, London.

出版信息

Arch Dis Child. 1995 Jul;73(1):66-9. doi: 10.1136/adc.73.1.66.

Abstract

The purpose of this study was to compare contemporary results of balloon dilatation and surgery for valvar aortic stenosis in infants and children in the five years between August 1988 and October 1993. Thirty four children underwent attempted balloon valvuloplasty (age 1 day-16 years, weight 1720 g-68 kg) (group 1), eight of whom were neonates with critical aortic stenosis. During the same period, 17 children underwent direct surgical valvotomy (group 2) (seven neonates). Successful balloon valvuloplasty was achieved in 33 (97%) with immediate reduction in the instantaneous systolic pressure gradient from 82 to 34 mm Hg (mean). There were two deaths in this group (both neonates), the second in a preterm neonate from necrotising enterocolitis. Complications requiring intervention in group 1 were aortic regurgitation in one and femoral artery injury in two. Follow up from four months to five years showed sustained results in most cases. There were two neonatal deaths in the surgical group. When the two groups were compared there was no significant difference in mortality, morbidity, or need for reintervention within 12 months. Deaths from both groups were attributed to small left ventricles. Hospital stay was significantly shorter in group 1. It is concluded that balloon dilatation for valvar aortic stenosis is effective and safe for the entire paediatric population. The results compare favourably with those of surgery.

摘要

本研究的目的是比较1988年8月至1993年10月这五年间婴儿和儿童瓣膜性主动脉狭窄球囊扩张术与手术治疗的当代结果。34名儿童接受了球囊瓣膜成形术(年龄1天至16岁,体重1720克至68千克)(第1组),其中8名是患有严重主动脉狭窄的新生儿。在同一时期,17名儿童接受了直接外科瓣膜切开术(第2组)(7名新生儿)。33例(97%)成功完成球囊瓣膜成形术,瞬间收缩压梯度立即从平均82毫米汞柱降至34毫米汞柱。该组有2例死亡(均为新生儿),第二例是一名早产新生儿死于坏死性小肠结肠炎。第1组需要干预的并发症包括1例主动脉瓣反流和2例股动脉损伤。4个月至5年的随访显示,大多数病例结果持续。手术组有2例新生儿死亡。两组比较,12个月内的死亡率、发病率或再次干预需求无显著差异。两组死亡均归因于左心室小。第1组的住院时间明显较短。结论是,瓣膜性主动脉狭窄的球囊扩张术对整个儿科人群有效且安全。其结果与手术治疗结果相比更具优势。

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