结直肠癌中DNA倍体的预后价值：一项前瞻性研究。
The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study.
作者信息
Kouri M, Pyrhönen S, Mecklin J P, Järvinen H, Laasonen A, Franssila K, Nordling S
机构信息
Department of Radiotherapy, Helsinki University Central Hospital, Finland.
出版信息
Br J Cancer. 1990 Dec;62(6):976-81. doi: 10.1038/bjc.1990.420.
Abstract
One hundred and fifty-seven patients with usual colorectal cancer were analysed prospectively for DNA-ploidy, DNA-index and S-phase fraction (SPF) using flow cytometry. An abnormal DNA-stemline was observed in 68% of tumours. The patients have been followed for a median of 36 months. In univariate analysis, tumour stage was the most significant prognostic factor. After excluding patients with stage D disease, DNA-aneuploidy was significantly associated with a shorter survival and a shorter disease free survival. SPF, however, did not correlate with prognosis. In multiple samples from the same tumour there was on average a 29% difference between the highest and the lowest SPF indicating considerable heterogeneity in proliferative activity within the tumours. In diploid tumours the variation was even higher. Patients with proximal tumours as well as female patients had DNA-diploid tumours more often than the others. This may indicate that there are different, so far unknown, aetiological factors leading to different types of ploidy pattern.
摘要
对157例常见结直肠癌患者进行前瞻性分析，采用流式细胞术检测其DNA倍体、DNA指数和S期细胞分数（SPF）。68%的肿瘤观察到异常DNA干系。患者中位随访36个月。单因素分析中，肿瘤分期是最显著的预后因素。排除D期疾病患者后，DNA非整倍体与较短生存期和无病生存期显著相关。然而，SPF与预后无关。同一肿瘤的多个样本中，最高和最低SPF平均相差29%，表明肿瘤内增殖活性存在相当大的异质性。在二倍体肿瘤中变异甚至更高。近端肿瘤患者以及女性患者比其他患者更常出现DNA二倍体肿瘤。这可能表明存在不同的、迄今未知的病因导致不同类型的倍体模式。
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