Lam T H, Kung I T, Wong C M, Lam W K, Kleevens J W, Saw D, Hsu C, Seneviratne S, Lam S Y, Lo K K
Department of Community Medicine, University of Hong Kong.
Br J Cancer. 1987 Nov;56(5):673-8. doi: 10.1038/bjc.1987.264.
In a case control study in Hong Kong, 445 cases of Chinese female lung cancer patients all confirmed pathologically were compared with 445 Chinese female healthy neighbourhood controls matched for age. The predominant histological type was adenocarcinoma (47.2%). The relative risk (RR) in ever-smokers was 3.81 (P less than 0.001, 95% CI = 2.86, 5.08). The RRs were statistically significantly raised for all major cell types with significant trends between RR and amount of tobacco smoked daily. Among never smoking women, RR for passive smoking due to a smoking husband was 1.65 (P less than 0.01, 95% CI = 1.16, 2.35) with a significant trend between RR and amount smoked daily by the husband. When broken down by cell types, the numbers were substantial only for adenocarcinoma (RR = 2.12, P less than 0.01, 95% CI = 1.32, 3.39) with a significant trend between RR and amount smoked daily by the husband. The results suggest that passive smoking is a risk factor for lung cancer, particularly adenocarcinoma in Hong Kong Chinese women who never smoked.
在香港进行的一项病例对照研究中，将445例经病理确诊的中国女性肺癌患者与445名年龄匹配的中国女性健康邻居对照进行比较。主要组织学类型为腺癌（47.2%）。曾经吸烟者的相对风险（RR）为3.81（P<0.001，95%可信区间=2.86，5.08）。所有主要细胞类型的RR均有统计学显著升高，且RR与每日吸烟量之间存在显著趋势。在从不吸烟的女性中，因丈夫吸烟而被动吸烟的RR为1.65（P<0.01，95%可信区间=1.16，2.35），且RR与丈夫每日吸烟量之间存在显著趋势。按细胞类型细分时，仅腺癌的数字可观（RR=2.12，P<0.01，95%可信区间=1.32，3.39），且RR与丈夫每日吸烟量之间存在显著趋势。结果表明，被动吸烟是肺癌的一个危险因素，尤其是在从不吸烟的香港中国女性中的腺癌。
