Rother U, Hänsch G, Rauterberg E W, Jungfer H, Rother K
Z Immunitatsforsch Immunobiol. 1978 Dec;155(2):118-29.
In serum exposed to acid pH (6.4), a serum activity was generated which lyzed unsensitized erythrocytes in the presence of EDTA. It was similar to the d.l. activity found following serum activation by inulin (2). In contrast to the d.l. generation by the classical or by the alternative pathway of C activation, the generation of d.l. by acid pH did not require C4 plus C2 or C3 plus factor B resp. It was, thus, not dependent on any hitherto known pathway of C activation. A similar activity appeared when NHS was centrifuged in a sucrose gradient at low ionic strength. Physicochemical alterations of the component proteins which influence their affinity for each other are seen as the basis for the activation of the attack phase of C.
在暴露于酸性pH值（6.4）的血清中，会产生一种血清活性，该活性在EDTA存在的情况下可裂解未致敏的红细胞。它类似于菊粉激活血清后发现的d.l.活性（2）。与经典或替代补体激活途径产生的d.l.不同，酸性pH值产生d.l.不需要C4加C2或C3加B因子。因此，它不依赖于任何迄今已知的补体激活途径。当正常人类血清在低离子强度的蔗糖梯度中离心时，会出现类似的活性。影响各成分蛋白质相互亲和力的物理化学改变被视为补体攻击阶段激活的基础。
