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利用近场静电纺丝制备噬菌体纳米纤维

Bacteriophage nanofiber fabrication using near field electrospinning.

作者信息

Sugimoto Ryota, Lee Ju Hun, Lee Ju-Hyuck, Jin Hyo-Eon, Yoo So Young, Lee Seung-Wuk

机构信息

Department of Bioengineering, University of California at Berkeley Berkeley CA 94720 USA

Biological Systems and Engineering, Lawrence Berkeley National Laboratory Berkeley CA 94720 USA.

出版信息

RSC Adv. 2019 Nov 28;9(67):39111-39118. doi: 10.1039/c9ra07510k. eCollection 2019 Nov 27.

Abstract

M13 bacteriophage (phage) nano- and microfibers were fabricated using electrospinning. Using liquid crystalline suspension of the phage, we successfully fabricated nano- and microscale pure phage fibers. Through a near field electrospinning process, we fabricated the desired phage fiber pattern with tunable direction and spacing. In addition, we demonstrated that the resulting phage fibers could be utilized as an electrostatic-stimulus responsive actuator. The near field electrospinning would be a very useful tool to design phage-based chemical sensors, tissue regenerative materials, energy generators, metallic and semiconductor nanowires in the future.

摘要

利用静电纺丝技术制备了M13噬菌体纳米和微米纤维。通过使用噬菌体的液晶悬浮液,我们成功制备了纳米级和微米级的纯噬菌体纤维。通过近场静电纺丝工艺,我们制备出了具有可调方向和间距的所需噬菌体纤维图案。此外,我们证明了所得的噬菌体纤维可用作静电刺激响应致动器。近场静电纺丝在未来将成为设计基于噬菌体的化学传感器、组织再生材料、能量发生器、金属和半导体纳米线的非常有用的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074f/9075989/d90dddcbc149/c9ra07510k-f1.jpg

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