National Reference Laboratory of Veterinary Drug Residues (HZAU), MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, Hubei 430070, China.
MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Adv Colloid Interface Sci. 2021 Aug;294:102475. doi: 10.1016/j.cis.2021.102475. Epub 2021 Jun 30.
Biofilm plays a vital role in the pathogenicity and resistance of bacteria, and is an important problem to be settled urgently in the treatment of bacterial diseases. Exploring effective strategies to control bacterial biofilm has become a hot research topic. Compared to other measures, organic nanomaterials have shown greater prospects in overcoming the problems of bacterial biofilms due to their unique properties. In order to explore more effective organic nanomaterials against biofilms, we used relevant keywords to search for related published publications on the Web of Science . On the basis of these searched publications, this review firstly summarized the properties, formulation, harmness, and treatment challenges of biofilm. Secondly, the current progress of organic nanomaterials against bacterial biofilm and its possible anti-biofilm mechanisms (e.g., reducing the adhesion of biofilms, enhancing the permeability of antimicrobial agents, maintaining drug stability, fighting against biofilm using specific actions) was analyzed. Thirdly, the influences on the anti-biofilm efficacy of organic nanomaterials were discussed from nanoparticles and biofilm characteristics. Finally, the challenges and prospects of organic nanoparticles against biofilm were concluded. This review may help researchers to realize the progress and challenges of nanoparticles against biofilm and thus help to design more efficient organic nanomaterial to fight against biofilms.
生物膜在细菌的致病性和耐药性中起着至关重要的作用，是细菌疾病治疗中亟待解决的一个重要问题。探索控制细菌生物膜的有效策略已成为一个热门研究课题。与其他措施相比，由于有机纳米材料具有独特的性质，因此在克服细菌生物膜问题方面显示出更大的前景。为了探索更有效的针对生物膜的有机纳米材料，我们使用相关关键字在 Web of Science 上搜索了相关的已发表出版物。在这些已搜索出版物的基础上，本综述首先总结了生物膜的特性、制剂、危害性和治疗挑战。其次，分析了有机纳米材料对细菌生物膜的当前进展及其可能的抗生物膜机制（例如，减少生物膜的黏附、增强抗菌剂的渗透性、保持药物稳定性、利用特定作用对抗生物膜）。第三，从纳米颗粒和生物膜特性两个方面讨论了有机纳米材料对抗生物膜功效的影响。最后，总结了有机纳米颗粒对抗生物膜的挑战和前景。本综述可能有助于研究人员了解纳米颗粒对抗生物膜的进展和挑战，从而有助于设计更有效的有机纳米材料来对抗生物膜。
