Gao Daqian, Zhang Yidan, Bowers Daniel T, Liu Wanjun, Ma Minglin
Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA.
APL Bioeng. 2021 Jul 9;5(3):031503. doi: 10.1063/5.0046682. eCollection 2021 Sep.
Diabetic wounds often have a slow healing process and become easily infected owing to hyperglycemia in wound beds. Once planktonic bacterial cells develop into biofilms, the diabetic wound becomes more resistant to treatment. Although it remains challenging to accelerate healing in a diabetic wound due to complex pathology, including bacterial infection, high reactive oxygen species, chronic inflammation, and impaired angiogenesis, the development of multifunctional hydrogels is a promising strategy. Multiple functions, including antibacterial, pro-angiogenesis, and overall pro-healing, are high priorities. Here, design strategies, mechanisms of action, performance, and application of functional hydrogels are systematically discussed. The unique properties of hydrogels, including bactericidal and wound healing promotive effects, are reviewed. Considering the clinical need, stimuli-responsive and multifunctional hydrogels that can accelerate diabetic wound healing are likely to form an important part of future diabetic wound management.
糖尿病伤口通常愈合过程缓慢，且由于伤口床中的高血糖而容易感染。一旦浮游细菌细胞形成生物膜，糖尿病伤口就会对治疗产生更强的抵抗力。尽管由于包括细菌感染、高活性氧、慢性炎症和血管生成受损在内的复杂病理状况，加速糖尿病伤口的愈合仍然具有挑战性，但多功能水凝胶的开发是一种有前景的策略。多种功能，包括抗菌、促血管生成和整体促进愈合，是高度优先考虑的事项。在此，系统地讨论了功能性水凝胶的设计策略、作用机制、性能和应用。综述了水凝胶的独特性质，包括杀菌和促进伤口愈合的作用。考虑到临床需求，能够加速糖尿病伤口愈合的刺激响应性和多功能水凝胶可能会成为未来糖尿病伤口管理的重要组成部分。
