Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Nat Rev Neurosci. 2021 Sep;22(9):553-572. doi: 10.1038/s41583-021-00488-y. Epub 2021 Jul 21.
The susceptibility of the brain to ischaemic injury dramatically limits its viability following interruptions in blood flow. However, data from studies of dissociated cells, tissue specimens, isolated organs and whole bodies have brought into question the temporal limits within which the brain is capable of tolerating prolonged circulatory arrest. This Review assesses cell type-specific mechanisms of global cerebral ischaemia, and examines the circumstances in which the brain exhibits heightened resilience to injury. We suggest strategies for expanding such discoveries to fuel translational research into novel cytoprotective therapies, and describe emerging technologies and experimental concepts. By doing so, we propose a new multimodal framework to investigate brain resuscitation following extended periods of circulatory arrest.
大脑对缺血性损伤的敏感性在血流中断后极大地限制了其存活能力。然而，来自分离细胞、组织标本、离体器官和整体动物研究的数据对大脑能够耐受长时间循环停止的时间限制提出了质疑。本综述评估了全脑缺血的细胞类型特异性机制，并研究了大脑表现出更高损伤抗性的情况。我们提出了将这些发现扩展为新型细胞保护治疗转化研究的策略，并描述了新兴技术和实验概念。通过这样做，我们提出了一个新的多模态框架来研究延长循环停止后的大脑复苏。
