Department of Biotechnology, Mizoram University, Aizawl, Mizoram, 796004, India.
Department of Pathology, Civil Hospital, Aizawl, Mizoram, 796001, India.
J Health Popul Nutr. 2021 Jul 22;40(1):32. doi: 10.1186/s41043-021-00257-8.
Over the last few decades, Mizoram has shown an increase in cases of type 2 diabetes mellitus; however, no in-depth scientific records are available to understand the occurrence of the disease. In this study, 500 patients and 500 healthy controls were recruited to understand the possible influence of their dietary and lifestyle habits in relation with type 2 diabetes mellitus. A multivariate analysis using Cox regression was carried out to find the influence of dietary and lifestyle factors, and an unpaired t test was performed to find the difference in the levels of biochemical tests. Out of 500 diabetic patients, 261 (52.3%) were males and 239 (47.7%) were females, and among the control group, 238 (47.7%) were males and 262 (52.3%) were females. Fermented pork fat, Sa-um (odds ratio (OR) 18.98), was observed to be a potential risk factor along with tuibur (OR 0.1243) for both males and females. Creatinine level was found to be differentially regulated between the male and female diabetic patients. This is the first report of fermented pork fat and tobacco (in a water form) to be the risk factors for diabetes. The unique traditional foods like Sa-um and local lifestyle habits like tuibur of the Mizo population may trigger the risk for the prevalence of the disease, and this may serve as a model to study other populations with similar traditional practices.
在过去的几十年中, 米佐拉姆邦 2 型糖尿病的发病率有所上升; 然而, 目前还没有深入的科学记录来了解这种疾病的发生情况。 在这项研究中, 招募了 500 名患者和 500 名健康对照者, 以了解他们的饮食和生活方式习惯与 2 型糖尿病之间可能存在的影响。 采用 Cox 回归多变量分析来发现饮食和生活方式因素的影响, 并进行了非配对 t 检验来发现生化测试水平的差异。 在 500 名糖尿病患者中, 男性 261 人(52.3%), 女性 239 人(47.7%); 在对照组中, 男性 238 人(47.7%), 女性 262 人(52.3%)。 发酵猪肉脂肪(Sa-um)(男性和女性的比值比(OR)分别为 18.98 和 18.98)和烟草(水形式)(男性和女性的 OR 分别为 0.1243 和 0.1243)被观察为男性和女性的潜在危险因素。 发现男性和女性糖尿病患者的肌酐水平存在差异调节。 这是首次报道发酵猪肉脂肪和烟草(水形式)是糖尿病的危险因素。 米佐拉姆邦独特的传统食品,如 Sa-um 和当地的生活方式,如 tuibur, 可能会引发这种疾病的流行风险, 这可能成为研究具有类似传统习俗的其他人群的模型。