Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, U.K.
Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt.
Emerg Top Life Sci. 2021 Nov 12;5(5):691-697. doi: 10.1042/ETLS20210169.
The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.
DNA 或 RNA 骨架的修饰是治疗性寡核苷酸、合成生物学和生物技术的新兴技术。尽管已经报道了大量的人工骨架，但它们的巨大潜力尚未得到充分利用。有限的合成可及性仍然是限制骨架修饰寡核苷酸更广泛应用的主要瓶颈。因此，迫切需要各种易于获得的人工骨架和将其引入寡核苷酸的稳健方法，以充分发挥它们在治疗、合成生物学和生物技术中的潜力。
