Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Chem Commun (Camb). 2011 Jul 7;47(25):7018-24. doi: 10.1039/c1cc11021g. Epub 2011 Apr 11.
Research in nucleic acids has made major advances in the past decade in multiple fields of science and technology. Here we discuss some of the most important findings in DNA and RNA research in the fields of biology, chemistry, biotechnology, synthetic biology, nanostructures and optical materials, with emphasis on how chemistry has impacted, and is impacted by, these developments. Major challenges ahead include the development of new chemical strategies that allow synthetically modified nucleic acids to enter into, and function in, living systems.
在过去的十年中，核酸研究在多个科学和技术领域取得了重大进展。在这里，我们讨论了生物学、化学、生物技术、合成生物学、纳米结构和光学材料等领域中 DNA 和 RNA 研究的一些最重要的发现，并重点介绍了化学如何影响这些发展以及这些发展如何影响化学。未来的主要挑战包括开发新的化学策略，使合成修饰的核酸能够进入并在活细胞中发挥功能。
