Romanian Academic Society, 020071 Bucharest, Romania.
Department of Pharmacology, Titu Maiorescu University, 031593 Bucharest, Romania.
Int J Environ Res Public Health. 2021 Jul 11;18(14):7415. doi: 10.3390/ijerph18147415.
To provide health-related quality of life (HRQoL) data to support health technology assessment (HTA) and reimbursement decisions in Romania, by developing a country-specific value set for the EQ-5D-3L questionnaire.
We used the cTTO method to elicit health state values using a computer-assisted personal interviewing approach. Interviews were standardized following the most recent version of the EQ-VT protocol developed by the EuroQoL Foundation. Thirty EQ-5D-3L health states were randomly assigned to respondents in blocks of three. Econometric modeling was used to estimate values for all 243 states described by the EQ-5D-3L.
Data from 1556 non-institutionalized adults aged 18 years and older, selected from a national representative sample, were used to build the value set. All tested models were logically consistent; the final model chosen to generate the value set was an interval regression model. The predicted EQ-5D-3L values ranged from 0.969 to 0.399, and the relative importance of EQ-5D-3L dimensions was in the following order: mobility, pain/discomfort, self-care, anxiety/depression, and usual activities.
These results can support reimbursement decisions and allow regional cross-country comparisons between health technologies. This study lays a stepping stone in the development of a health technology assessment process more driven by locally relevant data in Romania.
通过为 EQ-5D-3L 问卷开发特定于罗马尼亚的效用值量表，为罗马尼亚的卫生技术评估（HTA）和报销决策提供与健康相关的生活质量（HRQoL）数据。
我们使用 cTTO 方法通过计算机辅助个人访谈方法来获取健康状态值。访谈按照 EuroQoL 基金会开发的最新版 EQ-VT 协议进行标准化。受访者将随机分配到 3 个一组的 30 个 EQ-5D-3L 健康状态中。使用计量经济学模型来估算 EQ-5D-3L 描述的所有 243 个状态的价值。
该效用值量表是基于全国代表性样本中 1556 名 18 岁及以上非住院成年人的数据构建的。所有测试的模型在逻辑上都是一致的；最终选择的生成效用值量表的模型是区间回归模型。预测的 EQ-5D-3L 值范围从 0.969 到 0.399，EQ-5D-3L 维度的相对重要性依次为：行动能力、疼痛/不适、自我护理、焦虑/抑郁和日常活动。
这些结果可以支持报销决策，并允许在罗马尼亚进行地区间跨国的卫生技术比较。这项研究为罗马尼亚发展更依赖于本地相关数据的卫生技术评估过程奠定了基石。
