来自内生真菌.sp.的葎草烷型大环倍半萜类化合物
Humulane-Type Macrocyclic Sesquiterpenoids From the Endophytic Fungus sp. of .
作者信息
Wang Fu-Run, Yang Li, Kong Fan-Dong, Ma Qing-Yun, Xie Qing-Yi, Wu You-Gen, Dai Hao-Fu, Chen Ping, Xiao Na, Zhao You-Xing
机构信息
Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, China.
Key Laboratory for Quality Regulation of Tropical Horticultural Crops of Hainan Province, College of Horticulture, Hainan University, Haikou, China.
出版信息
Front Chem. 2021 Dec 16;9:797858. doi: 10.3389/fchem.2021.797858. eCollection 2021.
Three new humulane-type sesquiterpenoids, penirolide A (), penirolide B (), and 10-acetyl-phomanoxide (), together with three known compounds aurasperone A (), pughiinin A (), and cyclo(l-Leu-l-Phe) () were isolated from the endophytic fungus sp derived from the leaves of L. Their structures including their absolute configurations were determined based on the analysis of NMR and HRESIMS spectra, NMR chemical shifts, and ECD calculations. Compounds , , , and significantly inhibited glucagon-induced hepatic glucose production, with EC values of 33.3, 36.1, 18.8, and 32.1 μM, respectively. Further study revealed that compounds , , , and inhibited hepatic glucose production by suppression of glucagon-induced cAMP accumulation.
从来源于紫苏叶的内生真菌中分离得到了三种新的葎草烷型倍半萜，紫苏内酯A（）、紫苏内酯B（）和10-乙酰基-佛木烷氧化物（），以及三种已知化合物奥司珀酮A（）、普氏菌素A（）和环（L-亮氨酸-L-苯丙氨酸）（）。基于核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）光谱分析、NMR化学位移以及电子圆二色谱（ECD）计算确定了它们的结构，包括其绝对构型。化合物、、和显著抑制胰高血糖素诱导的肝葡萄糖生成，其半数有效浓度（EC）值分别为33.3、36.1、18.8和32.1μM。进一步研究表明，化合物、、和通过抑制胰高血糖素诱导的环磷酸腺苷（cAMP）积累来抑制肝葡萄糖生成。
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