Department of Ophthalmology, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Health Science University, Istanbul, Turkey.
Department of Cardiology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Arq Bras Oftalmol. 2021 Jul 14;84(5):467-473. doi: 10.5935/0004-2749.20210077. eCollection 2021.
To comparatively evaluate the subfoveal choroidal thickness and the peripapillary retinal nerve fiber layer thickness in patients with chronic heart failure relative to control subjects.
A total of 72 chronic heart failure patients and 40 healthy control subjects were enrolled in this study. The patients were categorized into 2 groups: group 1: patients with 30-50% left ventricle ejection fraction and group 2: patients with the corresponding fraction value of <30%. The subfoveal choroidal thickness and the peripapillary retinal nerve fiber layer thickness were measured by spectral domain-optical coherence tomography.
The mean subfoveal choroidal thickness was 250.24 ± 68.34 µm in group 1 and 216.72 ± 71.24 µm in group 2, while it was 273.64 ± 77.68 µm in the control group. The differences among the 3 groups were statistically significant. The average peripapillary retinal nerve fiber layer thicknesses were 100.34 ± 8.24, 95.44 ± 6.67, and 102.34 ± 8.24 µm, respectively. No significant differences were noted in the peripapillary retinal nerve fiber layer thicknesses between group 1 and control group, but it was significantly lower in group 2.
Our study thus revealed that the subfoveal choroidal thickness was lower in patients belonging to both the chronic heart failure groups in comparison to those in the control group. However, the alteration in the peripapillary retinal nerve fiber layer thickness was noted in only patients with <30% left ventricle ejection fraction. In the clinical practice, reductions in these values are correlated with decreased left ventricle ejection fraction, which may be important for the follow-up of chorioretinal diseases and the evaluation of glaucoma risks in patients with chronic heart failures.
比较慢性心力衰竭患者与对照组患者的中心凹下脉络膜厚度和视盘周围视网膜神经纤维层厚度。
本研究共纳入 72 例慢性心力衰竭患者和 40 名健康对照者。将患者分为 2 组：组 1：左心室射血分数 30%-50%的患者；组 2：相应分数值<30%的患者。应用频域光相干断层扫描测量中心凹下脉络膜厚度和视盘周围视网膜神经纤维层厚度。
组 1 的平均中心凹下脉络膜厚度为 250.24±68.34μm，组 2 为 216.72±71.24μm，对照组为 273.64±77.68μm。3 组间差异有统计学意义。平均视盘周围视网膜神经纤维层厚度分别为 100.34±8.24μm、95.44±6.67μm 和 102.34±8.24μm。组 1 与对照组之间视盘周围视网膜神经纤维层厚度无显著差异，但组 2 明显较低。
本研究表明，与对照组相比，慢性心力衰竭患者的中心凹下脉络膜厚度在两组中均较低。然而，仅在左心室射血分数<30%的患者中观察到视盘周围视网膜神经纤维层厚度的改变。在临床实践中，这些值的降低与左心室射血分数降低相关，这可能对脉络膜视网膜疾病的随访和慢性心力衰竭患者青光眼风险的评估很重要。
