患者对类器官的衍生和使用的看法。
Patients' perspectives on the derivation and use of organoids.
机构信息
Berman Institute of Bioethics, Johns Hopkins University, 1809 Ashland Avenue, Baltimore, MD 21205, USA.
Berman Institute of Bioethics, Johns Hopkins University, 1809 Ashland Avenue, Baltimore, MD 21205, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Stem Cell Reports. 2021 Aug 10;16(8):1874-1883. doi: 10.1016/j.stemcr.2021.07.004. Epub 2021 Jul 29.
Organoid research is enhancing understanding of human development and diseases as well as aiding in medication development and selection, raising hopes for even more future therapeutic options. Nevertheless, this work raises important ethical issues and there is a paucity of data regarding patients' perspectives on them. We report on 60 interviews with adult patients or parents of pediatric patients from diverse disease populations who receive medical care at a major academic research institution in the United States. Interviewees expressed broad support for organoid development and use. However, patients viewed brain organoids, and sometimes gonadal organoids, as morally distinct; and some organoid research poses moral concerns. Nonetheless, patients generally understood the potential value of such research and approved of it, provided it was aimed at good intent and conducted with ethical oversight and a robust consent process. These data should help inform conceptual and policy deliberations about appropriate organoid use.
类器官研究增进了人们对人类发育和疾病的理解，有助于药物开发和选择，为未来更多的治疗选择带来了希望。然而，这项工作引发了一些重要的伦理问题，并且关于患者对这些问题的看法的数据也很匮乏。我们报告了对在美国一家主要学术研究机构接受医疗的来自不同疾病群体的 60 名成年患者或儿科患者的父母进行的采访。受访者对类器官的开发和使用表示广泛支持。然而，患者认为脑类器官，有时是性腺类器官，在道德上是有区别的；并且一些类器官研究引发了道德问题。尽管如此，患者通常理解此类研究的潜在价值，并在符合良好意图、经过伦理监督和强有力的同意程序的情况下，对其表示认可。这些数据应该有助于为类器官的适当使用提供概念和政策方面的信息。
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