Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Microb Pathog. 2021 Sep;158:105115. doi: 10.1016/j.micpath.2021.105115. Epub 2021 Jul 28.
In recent years, extreme attention has been focused on the role of immunometabolism in the regulation of immune cell responses in healthy individuals during infection, autoimmunity, and cancer. In the infection biology area, it has been shown that there is a close relationship between the immune system and the host metabolic changes. Brucella species is an intracellular coccobacillus that infects humans and mammals, which led to brucellosis. Brucella species with host-specific evolutionary mechanisms allow it to hide from or manipulate cellular immunity and achieve intracellular persistence. Intracellular bacterial pathogens such as Brucella species also employ host cell resources to replicate and persist inside the host. Targeting these host systems is one promising strategy for developing novel antimicrobials to tackle intracellular infections. This study will summarize the role of metabolic reprogramming in immune cells and their relationship to brucellosis.
近年来，人们对免疫代谢在调节感染、自身免疫和癌症患者免疫细胞反应中的作用给予了极大的关注。在感染生物学领域，已经表明免疫系统和宿主代谢变化之间存在密切关系。布鲁氏菌属是一种感染人类和哺乳动物的细胞内球杆菌，导致布鲁氏菌病。具有宿主特异性进化机制的布鲁氏菌属能够躲避或操纵细胞免疫，从而实现细胞内的持续存在。像布鲁氏菌属这样的细胞内细菌病原体也利用宿主细胞资源在宿主内部复制和持续存在。针对这些宿主系统是开发新型抗菌药物来应对细胞内感染的一种很有前途的策略。本研究将总结代谢重编程在免疫细胞中的作用及其与布鲁氏菌病的关系。
