Laboratory of Biochemistry, Biotechnology, Health and the Environment, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Université Mohammed V de Rabat, Faculté de Médecine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie, Rabat, Morocco.
Biomed Res Int. 2021 Jul 21;2021:6695311. doi: 10.1155/2021/6695311. eCollection 2021.
is a medicinal plant of the family, widely used in traditional medicine. This study is aimed at investigating the functional variability of phenolic compounds in different parts (leaves, stems, flowers, roots, and seeds) of methanolic extracts and at assessing their antidiabetic, antioxidant, and antibacterial activities. The results of HPLC-DAD-QTOF-MS indicated the presence of 25 phenolic compounds with a remarkable variability between plant parts; high levels were registered in chlorogenic, vanillic, 3,4-dihydroxybenzoic, and 3-hydroxybenzoic acids; hesperidin; and luteolin. fruits and stems presented higher antioxidant activities. The extracts inhibited the growth of five pathogenic bacteria with MIC values documented between 7.81 and 31.25 mg/mL. antihyperglycemic effect revealed higher effect in flowers (2921.84 g/mL) and seeds (2992.75 g/mL) against -glucosidase and of leaves (2156.80 g/mL) and roots (2357.30 g/mL) against -amylase. The findings of this showed that is a promising source for antidiabetic bioactive compounds. However, further investigations regarding the evaluation of antidiabetic effects of these compounds are needed.
是唇形科的一种药用植物，在传统医学中被广泛应用。本研究旨在调查不同部位（叶、茎、花、根和种子）的甲醇提取物中酚类化合物的功能变异性，并评估其抗糖尿病、抗氧化和抗菌活性。HPLC-DAD-QTOF-MS 的结果表明，存在 25 种酚类化合物，植物部位之间存在显著的变异性；绿原酸、香草酸、3,4-二羟基苯甲酸和 3-羟基苯甲酸、橙皮苷和木樨草素含量较高。果实和茎表现出较高的抗氧化活性。提取物抑制了五种致病菌的生长，MIC 值记录在 7.81 到 31.25mg/mL 之间。对 -葡萄糖苷酶的抑制作用显示，花（2921.84μg/mL）和种子（2992.75μg/mL）的降血糖效果更好，对 -淀粉酶的抑制作用显示，叶（2156.80μg/mL）和根（2357.30μg/mL）的降血糖效果更好。这些发现表明，是一种有前途的抗糖尿病生物活性化合物的来源。然而，需要进一步研究这些化合物的抗糖尿病作用。
