Penn Program on Precision Medicine for the Brain, Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Philosophy, Institute for Philosophy and Public Policy, George Mason University, Fairfax, Virginia, USA.
Alzheimers Dement. 2022 Mar;18(3):513-521. doi: 10.1002/alz.12424. Epub 2021 Aug 2.
Paradoxical lucidity in dementia is a clinically significant but understudied phenomenon. A provisional definition was proposed by the 2018 National Institute on Aging expert workshop and published in Alzheimer's and Dementia. However, several conceptual features of this definition remain vague, creating barriers to robust clinical research. Here, we critically analyze the provisional definition and present a refined definition that can be applied in clinical research. The refined definition is based on an analytic process our research group recently undertook to operationalize paradoxical lucidity for our own study protocol. Our goal is to facilitate debate and potentially harmonize interpretations of paradoxical lucidity among research groups.
痴呆症中的矛盾清晰是一种具有临床意义但研究不足的现象。2018 年美国国家老龄化研究所专家研讨会提出了一个暂定定义，并发表在《阿尔茨海默病与痴呆症》上。然而，该定义的几个概念特征仍然模糊不清，这给强有力的临床研究造成了障碍。在这里，我们批判性地分析了暂定定义，并提出了一个更精炼的定义，可应用于临床研究。该精炼定义基于我们研究小组最近为自己的研究方案将矛盾清晰概念化的分析过程。我们的目标是促进辩论，并有可能在研究小组之间协调对矛盾清晰的解释。
