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壳聚糖包封噬菌体鸡尾酒治疗细菌性腹泻。

Encapsulation of bacteriophage cocktail into chitosan for the treatment of bacterial diarrhea.

机构信息

Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

出版信息

Sci Rep. 2021 Aug 2;11(1):15603. doi: 10.1038/s41598-021-95132-1.

DOI:10.1038/s41598-021-95132-1
PMID:34341399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8329165/
Abstract

The therapeutic effectiveness of a chitosan encapsulated bacteriophage cocktail as a smart biocontrol agent was evaluated in this study to be used as a preventative and treatment option for gastrointestinal infections. To evaluate the effect of the bacteriophage formulation on the treatment of gastrointestinal infection, rats were infected with Salmonella enterica, Shigella flexneri, and Escherichia coli. The rats were weighed and their stools cultured. The results showed that the group which had the chitosan encapsulated bacteriophage cocktail did not lose weight after 3 days and had significantly lower group weight changes. Weight loss was significant in the rats that had cefixime administered instead. Positive cultured stools were reduced after 4 days compared to 2 days in the treated group with the chitosan encapsulated bacteriophage cocktail. The chitosan encapsulated bacteriophage cocktail can therefore be effective in the treatment of gastrointestinal infections.

摘要

本研究评估了壳聚糖包封噬菌体鸡尾酒作为智能生物防治剂的治疗效果，将其用作预防和治疗胃肠道感染的一种选择。为了评估噬菌体配方对胃肠道感染治疗的效果，用肠炎沙门氏菌、福氏志贺菌和大肠杆菌感染大鼠。对大鼠进行称重和粪便培养。结果表明，3 天后，壳聚糖包封噬菌体鸡尾酒组的大鼠体重没有减轻，体重变化明显较小。而给予头孢克肟的大鼠体重减轻更为明显。与壳聚糖包封噬菌体鸡尾酒治疗组相比，治疗组 4 天后阳性培养粪便较 2 天后减少。因此，壳聚糖包封噬菌体鸡尾酒可有效治疗胃肠道感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/02f8b1b2715f/41598_2021_95132_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/b13679c4fec7/41598_2021_95132_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/04396869f903/41598_2021_95132_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/83d212b0d468/41598_2021_95132_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/455ada52daa1/41598_2021_95132_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/cdd621fd7d1b/41598_2021_95132_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/5063f704efcc/41598_2021_95132_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/79d10fcd5a63/41598_2021_95132_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/5b78ff62b2e8/41598_2021_95132_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/02f8b1b2715f/41598_2021_95132_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/b13679c4fec7/41598_2021_95132_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/04396869f903/41598_2021_95132_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/83d212b0d468/41598_2021_95132_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/455ada52daa1/41598_2021_95132_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/cdd621fd7d1b/41598_2021_95132_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/5063f704efcc/41598_2021_95132_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/79d10fcd5a63/41598_2021_95132_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/5b78ff62b2e8/41598_2021_95132_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8329165/02f8b1b2715f/41598_2021_95132_Fig9_HTML.jpg

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[2]
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[3]
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[4]
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Pharmaceutics. 2024-9-13

[5]
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Antibiotics (Basel). 2024-7-15

[6]
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Viruses. 2024-5-31

[7]
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Pharmaceutics. 2024-3-8

[8]
Isolation and encapsulation of bacteriophage with chitosan nanoparticles for biocontrol of multidrug-resistant methicillin-resistant Staphylococcus aureus isolated from broiler poultry farms.

Sci Rep. 2024-2-26

[9]
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[10]
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本文引用的文献

[1]
In Vitro and In Vivo Gastrointestinal Survival of Non-Encapsulated and Microencapsulated Bacteriophages: Implications for Bacteriophage Therapy in Poultry.

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J Mater Chem B. 2015-9-14

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Front Microbiol. 2019-3-21

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Gastroenterol Hepatol Bed Bench. 2017

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Chitosan Nanoparticles as Carriers for the Delivery of ΦKAZ14 Bacteriophage for Oral Biological Control of Colibacillosis in Chickens.

Molecules. 2016-3-14

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