Center of Allergy & Environment (ZAUM), Technical University of Munich (TUM) and Helmholtz Center Munich, German Research Center for Environmental Health (HMGU), Munich, Germany.
Member of the German Center of Lung Research (DZL), CPC-M, Munich, Germany.
Allergy. 2022 Mar;77(3):767-777. doi: 10.1111/all.15033. Epub 2021 Aug 11.
The proteins of the secretoglobin (SCGB) family are expressed by secretory tissues of barrier organs. They are embedded in immunoregulatory and anti-inflammatory processes of airway diseases. This review particularly illustrates the immune regulation of SCGBs by cytokines and their implication in the pathophysiology of airway diseases. The biology of SCGBs is a complex topic of increasing importance, as they are highly abundant in the respiratory tract and can also be detected in malignant tissues and as elements of immune control. In addition, SCGBs react to cytokines, they are embedded in Th1 and Th2 immune responses, and they are expressed in a manner dependent on cell maturation. The big picture of the SCGB family identifies these factors as critical elements of innate immune control at the epithelial barriers and highlights their potential for diagnostic assessment of epithelial activity. Some members of the SCGB family have so far only been superficially examined, but have high potential for translational research.
分泌球蛋白（SCGB）家族的蛋白由屏障器官的分泌组织表达。它们嵌入在气道疾病的免疫调节和抗炎过程中。这篇综述特别说明了细胞因子对 SCGB 的免疫调节及其在气道疾病病理生理学中的意义。SCGB 的生物学是一个日益重要的复杂课题，因为它们在呼吸道中含量非常丰富，也可以在恶性组织和免疫控制元件中检测到。此外，SCGB 对细胞因子有反应，它们嵌入 Th1 和 Th2 免疫反应中，并以依赖于细胞成熟的方式表达。SCGB 家族的全貌将这些因子确定为上皮屏障固有免疫控制的关键因素，并强调了它们用于评估上皮活性的诊断潜力。SCGB 家族的一些成员迄今仅进行了表面研究，但具有转化研究的巨大潜力。
