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一名德国旅行者中与登革热休克综合征相关的胆囊壁增厚——无手术治疗指征——病例报告

Gallbladder Wall Thickening associated with Dengue Shock Syndrome in a German traveller - no indication for surgical therapy - a case report.

作者信息

Freise Noemi F, Jensen Björn, Keitel Verena, Luedde Tom

机构信息

Department of Gastroenterology, Hepatology and Infectious Diseases, Duesseldorf University Hospital, Heinrich-Heine-University, Moorenstr. 5, 40225, Duesseldorf, Germany.

出版信息

Trop Dis Travel Med Vaccines. 2021 Aug 3;7(1):23. doi: 10.1186/s40794-021-00148-0.

Abstract

BACKGROUND

With the increasing number of dengue virus infections imported into Germany, knowledge about the different phases of the disease and possible complications is essential for the treatment of patients. The virus is endemic in the tropics and subtropics and up to 2.5 billion people are at risk of infection.

CASE PRESENTATION

Here we present a German traveller with dengue shock syndrome after returning from Thailand. After hospitalization the patient developed acute upper abdominal pain. The ultrasound findings were consistent with an acute acalculous cholecystitis, but were interpreted as dengue associated gallbladder wall thickening (GBWT). Therefore a surgical intervention was not indicated and would have been associated with an higher risk of complications in this situation. Under supportive care spontaneous regression of GBWT could be documented by sonography four days later as well as complete resolution of clinical symptoms.

CONCLUSION

GBWT in dengue virus infection mimicking acute cholecystitis is a differential diagnosis one should take into consideration in travellers returning from endemic areas and should be managed conservatively because of an high risk of bleeding and increased mortality under surgical therapy.

摘要

背景

随着输入德国的登革热病毒感染病例数量不断增加,了解该疾病的不同阶段及可能出现的并发症对于患者治疗至关重要。该病毒在热带和亚热带地区为地方性流行,多达25亿人有感染风险。

病例报告

在此,我们报告一名从泰国返回后出现登革热休克综合征的德国旅行者。住院后,患者出现急性上腹部疼痛。超声检查结果与急性非结石性胆囊炎相符,但被解释为登革热相关的胆囊壁增厚(GBWT)。因此,未进行手术干预,因为在这种情况下手术干预会带来更高的并发症风险。在支持性治疗下,四天后超声检查显示GBWT自发消退,临床症状也完全缓解。

结论

登革热病毒感染中模拟急性胆囊炎的GBWT是一种鉴别诊断,对于从流行地区返回的旅行者应予以考虑,并且由于手术治疗存在出血风险高和死亡率增加的情况,应采取保守治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8389/8336325/f0c79842962a/40794_2021_148_Fig1_HTML.jpg

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