Department of Chemistry, College of Sciences, Northeastern University, Box 332, Shenyang 110819, China.
ACS Appl Mater Interfaces. 2021 Aug 18;13(32):38127-38137. doi: 10.1021/acsami.1c12199. Epub 2021 Aug 4.
Combination therapy has attracted extensive interest in alleviating the shortcomings of monotherapy and enhancing the treatment efficacy. In this work, hollow mesoporous silica nanoparticles (HMSNs) play the role of nanocarriers in the delivery of Cu(II)-doped polydopamine (PDA), termed as HMSNs@PDA-Cu, for synergistic therapy. PDA acts as a traditional photothermal agent to realize photothermal treatment (PTT). Chemodynamic therapy (CDT) is realized by the reaction of Cu(II) with intracellular glutathione (GSH), and subsequently, the generated Cu(I) reacts with HO to produce toxic hydroxyl radical (OH) through a Fenton-like reaction. The photothermal performance of PDA is improved after its coordination with Cu(II). On the other hand, PDA exhibits superoxide dismutase (SOD)-mimicking activity. PDA converts O to HO and improves the production of HO, which promotes the therapeutic effect of CDT. Moreover, the high temperature caused by PTT further enhances the yield of OH for CDT. This nanotheranostic platform perfectly applied to the tumor depletion of mice, presenting great potential for cancer metastasis therapy in vitro and in vivo.
联合治疗在缓解单药治疗的缺点和提高治疗效果方面引起了广泛关注。在这项工作中，中空介孔硅纳米粒子（HMSNs）作为纳米载体在递送铜（II）掺杂的聚多巴胺（PDA）中发挥作用，称为 HMSNs@PDA-Cu，用于协同治疗。PDA 作为一种传统的光热剂来实现光热治疗（PTT）。通过 Cu（II）与细胞内谷胱甘肽（GSH）的反应实现化学动力学治疗（CDT），随后，生成的 Cu（I）通过芬顿样反应与 HO 反应生成有毒的羟基自由基（OH）。PDA 与 Cu（II）配位后提高了 PDA 的光热性能。另一方面，PDA 表现出超氧化物歧化酶（SOD）模拟活性。PDA 将 O 转化为 HO 并提高 HO 的生成，从而促进 CDT 的治疗效果。此外，PTT 产生的高温进一步增强了 CDT 中 OH 的生成。这种纳米治疗平台完美地应用于小鼠肿瘤耗竭，为体外和体内癌症转移治疗提供了巨大的潜力。
