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广西壮族自治区 HIV/AIDS 患者中肠道内人芽囊原虫和隐孢子虫的流行情况及其遗传特征。

Prevalence and genetic characteristics of Blastocystis hominis and Cystoisospora belli in HIV/AIDS patients in Guangxi Zhuang Autonomous Region, China.

机构信息

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); Key Laboratory of Parasite and Vector Biology, National Health Commission of People's Republic of China, WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.

The School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

出版信息

Sci Rep. 2021 Aug 5;11(1):15904. doi: 10.1038/s41598-021-94962-3.

DOI:10.1038/s41598-021-94962-3
PMID:34354101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8342556/
Abstract

Blastocystis hominis and Cystoisospora belli are considered to be common opportunistic intestinal protozoa in HIV/AIDS patients. In order to investigate the prevalence and genetic characteristics of B. hominis and C. belli in HIV/AIDS patients, a total of 285 faecal samples were individually collected from HIV/AIDS patients in Guangxi, China. B. hominis and C. belli were investigated by amplifying the barcode region of the SSU rRNA gene and the internal transcribed spacer 1 (ITS-1) region of the rRNA gene, respectively. Chi-square test or Fisher's exact test were conducted to assess the risk factors related to B. hominis and C. belli infection. The prevalence of B. hominis and C. belli was 6.0% (17/285) and 1.1% (3/285) respectively. Four genotypes of B. hominis were detected, with ST3 (n = 8) and ST1 (n = 6) being predominant, followed by ST6 (n = 2) and ST7 (n = 1). Females had a statistically higher prevalence of B. hominis (11.6%) than males (4.2%). The statistical analysis also showed that the prevalence of B. hominis was significantly associated with age group and educational level. Our study provides convincing evidence for the genetic diversity of B. hominis, which indicates its potential zoonotic transmission and is the first report on the molecular characteristics of C. belli in HIV/AIDS patients in China.

摘要

人芽囊原虫和贝氏等孢球虫被认为是 HIV/AIDS 患者中常见的机会性肠道原生动物。为了调查 HIV/AIDS 患者中人芽囊原虫和贝氏等孢球虫的流行情况和遗传特征，我们从中国广西的 HIV/AIDS 患者中分别采集了 285 份粪便样本。通过扩增 SSU rRNA 基因的条码区和 rRNA 基因的内部转录间隔区 1（ITS-1）区，分别检测了人芽囊原虫和贝氏等孢球虫。采用卡方检验或 Fisher 确切概率法评估与感染人芽囊原虫和贝氏等孢球虫相关的风险因素。人芽囊原虫和贝氏等孢球虫的流行率分别为 6.0%（17/285）和 1.1%（3/285）。共检测到 4 种人芽囊原虫基因型，以 ST3（n=8）和 ST1（n=6）为主，其次是 ST6（n=2）和 ST7（n=1）。女性感染人芽囊原虫的比例（11.6%）明显高于男性（4.2%）。统计分析还表明，人芽囊原虫的流行率与年龄组和教育程度显著相关。本研究为人芽囊原虫的遗传多样性提供了令人信服的证据，提示其具有潜在的人畜共患传播风险，也是中国首例关于 HIV/AIDS 患者中贝氏等孢球虫分子特征的报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8dc/8342556/8e5f9e3d38eb/41598_2021_94962_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8dc/8342556/c90e33257ffe/41598_2021_94962_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8dc/8342556/8e5f9e3d38eb/41598_2021_94962_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8dc/8342556/c90e33257ffe/41598_2021_94962_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8dc/8342556/8e5f9e3d38eb/41598_2021_94962_Fig2_HTML.jpg

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