Al-Jameel Suhailah S
Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
Saudi J Biol Sci. 2021 Aug;28(8):4446-4454. doi: 10.1016/j.sjbs.2021.04.041. Epub 2021 Apr 24.
Diabetes is an emerging health condition globally and is suggested to have a direct connection with the gut microbiota that determine our metabolic outcomes. Sensitivity to insulin and glucose metabolism is normal in healthy people as compared to those people who cannot maintain their glucose metabolism. One of the reasons of the differences is that healthy people have different microbiome that leads to achieve more short chain fatty acids and make up more branched amino acids, while the gut microbiota of the other group of people are more likely to produce compounds that affects glucose metabolism. Herein, this review will present the research related to the impact of gut microbes on diabetes carried out in the past decade. The review focus on the relation between gut microbiota and Type-1 Diabetes (T1D), Type-2 Diabetes (T2D), and how gut microbiota could be an alternative therapy for treatment of diabetes.
糖尿病是一种在全球范围内日益凸显的健康问题,并且被认为与决定我们代谢结果的肠道微生物群存在直接联系。与那些无法维持葡萄糖代谢的人相比,健康人的胰岛素敏感性和葡萄糖代谢是正常的。造成这种差异的原因之一是,健康人拥有不同的微生物群,这些微生物群能产生更多的短链脂肪酸并合成更多的支链氨基酸,而另一组人的肠道微生物群则更有可能产生影响葡萄糖代谢的化合物。在此,本综述将呈现过去十年中关于肠道微生物对糖尿病影响的相关研究。该综述聚焦于肠道微生物群与1型糖尿病(T1D)、2型糖尿病(T2D)之间的关系,以及肠道微生物群如何成为治疗糖尿病的一种替代疗法。