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用于细胞外分析物研究的单壁碳纳米管传感器平台。

Single-Walled Carbon Nanotube Sensor Platform for the Study of Extracellular Analytes.

作者信息

Stapleton Joseph A, Hofferber Eric M, Meier Jakob, Ramirez Ivon Acosta, Iverson Nicole M

机构信息

Department of Biological Systems Engineering, Institute of Agriculture and Natural Resources, College of Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska 68583-0726, United States.

出版信息

ACS Appl Nano Mater. 2021 Jan 22;4(1):33-42. doi: 10.1021/acsanm.0c01998. Epub 2020 Dec 23.

Abstract

Single-walled carbon nanotubes (SWNT) are attractive targets for the formation of high-density sensor arrays. Their small size and high reactivity could allow for the spatial and temporal study of extracellular products to a degree which greatly surpasses contemporary sensors. However, current methods of SWNT immobilization produce a low fluorescence yield that requires a combination of high magnification, exposure time, and laser intensity to combat, thus limiting the sensor's applications. In this work, a platform for the immobilization of SWNT sensors with increased fluorescence yield, longevity, fluorescence distribution, and fast reaction times is developed.

摘要

单壁碳纳米管(SWNT)是形成高密度传感器阵列的有吸引力的目标。它们的小尺寸和高反应性能够在一定程度上对细胞外产物进行空间和时间研究,这大大超越了当代传感器。然而,目前单壁碳纳米管的固定方法产生的荧光产率较低,需要高放大倍数、曝光时间和激光强度相结合才能克服,从而限制了该传感器的应用。在这项工作中,开发了一个用于固定单壁碳纳米管传感器的平台,该平台具有提高的荧光产率、寿命、荧光分布和快速反应时间。

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