Hong Ji Young, Kim Song Yee, Chung Kyung Soo, Kim Eun Young, Jung Ji Ye, Park Moo Suk, Kang Young Ae, Kim Se Kyu, Chang Joon, Kim Young Sam
Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Qual Life Res. 2015 Oct;24(10):2549-58. doi: 10.1007/s11136-015-0979-6. Epub 2015 Apr 5.
This study evaluated the health-related quality of life measured using the EuroQol five-dimension questionnaire (EQ-5D) and the degree of airway obstruction in a Korean population using Korea National Health and Nutritional Examination Survey (KNHANES IV-V, 2007-2010) data.
A cross-sectional analysis examined 2356 subjects (1178 COPD patients, 1178 control subjects) aged ≥40 years and performed reliable spirometry as part of KNHANES IV-V. Baseline EQ-5D visual analog scale (VAS) and EQ-5D utility scores were obtained. A Tobit censored regression model was used to evaluate factors affecting EQ-5D in COPD patients.
The EQ-5D VAS and EQ-5D utility scores were significantly different among the COPD severity groups (P < 0.05). The mean EQ-5D VAS scores for patients with mild, moderate, and severe COPD were 73.0 (SD 18.6), 70.8 (19.1), and 60.9 (23.4), respectively. The mean utility scores were 0.90 (0.14) for patients with mild COPD, 0.89 (0.14) for patients with moderate COPD, and 0.84 (0.15) for patients with severe COPD. Factors influencing the EQ-5D utility score in patients with COPD were age, gender, household income, education level, severe airflow obstruction, and comorbidities.
The EQ-5D score could be a useful instrument for evaluating the quality of life of COPD patients in Korea. In Korean COPD patients, the main determinants of EQ-5D scores include older age, female gender, lower household income, lower education level, severe airflow obstruction, and many comorbid diseases.
本研究利用韩国国家健康与营养检查调查（KNHANES IV-V，2007 - 2010年）的数据，评估使用欧洲五维度健康量表（EQ-5D）测量的韩国人群与健康相关的生活质量以及气道阻塞程度。
一项横断面分析研究了2356名年龄≥40岁的受试者（1178名慢性阻塞性肺疾病（COPD）患者和1178名对照受试者），这些受试者作为KNHANES IV-V的一部分进行了可靠的肺功能测定。获取了基线EQ-5D视觉模拟量表（VAS）和EQ-5D效用得分。使用Tobit删失回归模型评估影响COPD患者EQ-5D的因素。
COPD严重程度组之间的EQ-5D VAS和EQ-5D效用得分存在显著差异（P < 0.05）。轻度、中度和重度COPD患者的平均EQ-5D VAS得分分别为73.0（标准差18.6）、70.8（19.1）和60.9（23.4）。轻度COPD患者的平均效用得分为0.90（0.14），中度COPD患者为0.89（0.14），重度COPD患者为0.84（0.15）。影响COPD患者EQ-5D效用得分的因素包括年龄、性别、家庭收入、教育水平、严重气流阻塞和合并症。
EQ-5D得分可能是评估韩国COPD患者生活质量的有用工具。在韩国COPD患者中，EQ-5D得分的主要决定因素包括年龄较大、女性、家庭收入较低、教育水平较低、严重气流阻塞和多种合并疾病。
