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瑜伽生活方式对脆弱人群脂质代谢的影响——一项基于社区的多中心随机对照试验

Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population-A Community Based Multicenter Randomized Controlled Trial.

作者信息

Nagarathna Raghuram, Kumar Saurabh, Anand Akshay, Acharya Ishwara N, Singh Amit Kumar, Patil Suchitra S, Latha Ramesh H, Datey Purnima, Nagendra Hongasandra Ramarao

机构信息

Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA), Bengaluru 560105, India.

Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.

出版信息

Medicines (Basel). 2021 Jul 13;8(7):37. doi: 10.3390/medicines8070037.

Abstract

Dyslipidemia poses a high risk for cardiovascular disease and stroke in Type 2 diabetes (T2DM). There are no studies on the impact of a validated integrated yoga lifestyle protocol on lipid profiles in a high-risk diabetes population. Here, we report the results of lipid profile values of 11,254 (yoga 5932 and control 5322) adults (20-70 years) of both genders with high risk (≥60 on Indian diabetes risk score) for diabetes from a nationwide rural and urban community-based two group (yoga and conventional management) cluster randomized controlled trial. The yoga group practiced a validated integrated yoga lifestyle protocol (DYP) in nine day camps followed by daily one-hour practice. Biochemical profiling included glycated hemoglobin and lipid profiles before and after three months. There was a significant difference between groups ( < 0.001 ANCOVA) with improved serum total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein in the yoga group compared to the control group. Further, the regulatory effect of yoga was noted with a significant decrease or increase in those with high or low values of lipids, respectively, with marginal or no change in those within the normal range. Yoga lifestyle improves and regulates (lowered if high, increased if low) the blood lipid levels in both genders of prediabetic and diabetic individuals in both rural and urban Indian communities.

摘要

血脂异常在2型糖尿病(T2DM)患者中会导致心血管疾病和中风的高风险。目前尚无关于经过验证的综合瑜伽生活方式方案对高危糖尿病患者血脂谱影响的研究。在此,我们报告了一项基于全国城乡社区的两组(瑜伽组和传统管理组)整群随机对照试验中11254名(瑜伽组5932名,对照组5322名)20至70岁糖尿病高危(印度糖尿病风险评分≥60)成年男女的血脂谱值结果。瑜伽组在9个日间营地中实施了经过验证的综合瑜伽生活方式方案(DYP),之后每天进行1小时练习。生化分析包括三个月前后的糖化血红蛋白和血脂谱。与对照组相比,瑜伽组血清总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白均有改善,两组间存在显著差异(协方差分析<0.001)。此外,观察到瑜伽的调节作用,血脂值高或低的人群分别有显著降低或升高,而正常范围内的人群变化很小或无变化。瑜伽生活方式可改善和调节(血脂高则降低,血脂低则升高)印度城乡社区糖尿病前期和糖尿病患者男女的血脂水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/411e/8303653/100722d381c9/medicines-08-00037-g001.jpg

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