Guerra D, Solé A, Camí J, Tobeña A
Department of Pharmacology, Hospital del Mar, Bellaterra, Spain.
Drug Alcohol Depend. 1987 Nov 30;20(3):261-70. doi: 10.1016/0376-8716(87)90036-6.
Neuropsychological performance before and after a rapid (1 week) detoxification treatment, was studied in heroin addicts. Ninety-three opioid dependents (DSM-III) were evaluated with a brief test battery assessing attention, memory and verbal fluency performance prior to their admission to a Detoxification Unit. Significant differences were noted between the addicts' performance and a group of 30 comparable normals, whose intellectual ability was similar. At re-evaluation addicts showed improvement in most measures, including general clinical status. Moreover, no differences between the sample of detoxificated addicts and controls on measures of neuropsychological performance were then detected. No relationship was found between psychopathological symptoms and neuropsychological functioning after the pharmacological detoxification of addicts. The length of addiction or drug consumption were not predictive of neuropsychological impairment in the present sample of heroin addicts.
对海洛因成瘾者在快速（1周）戒毒治疗前后的神经心理表现进行了研究。93名阿片类药物依赖者（符合《精神疾病诊断与统计手册》第三版标准）在进入戒毒所之前，通过一组简短测试对注意力、记忆力和语言流畅性进行了评估。结果发现，这些成瘾者的表现与一组30名智力水平相当的正常人存在显著差异。在重新评估时，成瘾者在大多数指标上都有改善，包括总体临床状况。此外，在神经心理表现指标上，戒毒后的成瘾者样本与对照组之间未发现差异。在成瘾者进行药物戒毒后，未发现精神病理症状与神经心理功能之间存在关联。在目前的海洛因成瘾者样本中，成瘾时间或药物使用量并不能预测神经心理损伤情况。
