Momin Munira M, Afreen Shaikh Darakhshan
Department of Pharmaceutics, SVKM, Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle, Mumbai, Maharashtra, India.
Department of Quality Assurance, Srinath College of Pharmacy, Bajaj Nagar, Waluj, Aurangabad, Maharashtra, India.
Crit Rev Ther Drug Carrier Syst. 2021;38(4):79-107. doi: 10.1615/CritRevTherDrugCarrierSyst.2021035767.
Several ocular drug delivery (ODD) systems, like hydrogels, microparticles, nano-emulsions, micro-emulsions, and liposomes have been researched, which can govern the drug release and sustain therapeutic levels for a delayed period in the eye. While new drugs targeting methods to the eye are possible by various nanoparticles. Presently in the market, there are fewer choices and need for novel nano-ocular delivery systems as well as therapies for prolonged delivery to the anterior and posterior eye segments. The primary objective of this article is to summarize current discoveries and proven activities of different nano- and microsystems in ODD. This article also depicts some regulatory updates along with the patents granted to the inventor for their work on ODD. Overall, a thought of how the different forthcoming of nanotechnologies like nanoparticles and nanomedicine can be used to investigate the frontiers of ODD and treatment can be withdrawn by this article.
已经对几种眼部给药（ODD）系统进行了研究，如水凝胶、微粒、纳米乳液、微乳液和脂质体，这些系统可以控制药物释放并在眼部维持一段时间的治疗水平。而各种纳米颗粒使将新药靶向眼部的方法成为可能。目前市场上的选择较少，需要新型的纳米眼部给药系统以及将药物长期递送至眼前段和眼后段的疗法。本文的主要目的是总结不同纳米和微系统在眼部给药方面的当前发现和已证实的活性。本文还描述了一些监管方面的更新以及授予发明者在眼部给药方面工作的专利。总体而言，本文可以引发这样一种思考，即如何利用纳米颗粒和纳米医学等不同的新兴纳米技术来探索眼部给药和治疗的前沿领域。
