Mental Health Center, West China Hospital, Sichuan University, No. 28 Dianxin South Street, Sichuan, 610041, Chengdu, China.
The Fourth People's Hospital of Chengdu, Chengdu, 610036, Sichuan, China.
BMC Psychiatry. 2021 Aug 9;21(1):395. doi: 10.1186/s12888-021-03400-1.
The Coronavirus Disease 2019 (COVID-19) pandemic continues to threaten the physical and mental health of people across the world. This study aimed to understand the psychological impact of this disease on adolescents with major depressive disorder (MDD) at 1 month after the start of the outbreak in China.
Using the Children's Impact of Event Scale (CRIES-13) questionnaire, we investigated the occurrence of posttraumatic stress disorder (PTSD) in two groups of adolescents: MDD patients who were in continuous antidepressant therapy and healthy controls. Total scores and factor subscores were compared between the two groups and subgroups stratified by sex and school grade. Logistic regression was used to identify variables associated with high total CRIES-13 scores.
Compared to controls (n = 107), the MDD group (n = 90) had higher total CRIES-13 scores and a higher proportion with a total score ≥ 30. They also had a lower intrusion subscore and a higher arousal subscore. In the MDD group, males and females did not differ significantly in total CRIES-13 scores or factor subscores, but junior high school students had higher avoidance subscores than senior high school students. Logistic regression showed high total CRIES-13 scores to be associated with MDD and the experience of "flashbacks" or avoidance of traumatic memories associated with COVID-19.
It is crucial to understand the psychological impact of COVID-19 on adolescents with MDD in China, especially females and junior high school students. Long-term monitoring of adolescents with a history of mental illness is required to further understand these impacts.
ChiCTR, ChiCTR2000033402 , Registered 31 May 2020.
2019 年冠状病毒病（COVID-19）大流行继续威胁着全世界人民的身心健康。本研究旨在了解 COVID-19 对中国疫情爆发后 1 个月时患有重度抑郁症（MDD）的青少年的心理影响。
使用儿童创伤后应激反应量表（CRIES-13）问卷，我们调查了两组青少年的创伤后应激障碍（PTSD）发生率：正在持续接受抗抑郁治疗的 MDD 患者和健康对照者。比较两组和按性别和年级分层的亚组之间的总分和因子分。使用逻辑回归识别与高总 CRIES-13 评分相关的变量。
与对照组（n=107）相比，MDD 组（n=90）的总 CRIES-13 评分更高，总分≥30 的比例更高。他们的闯入因子分较低，唤醒因子分较高。在 MDD 组中，男性和女性的总 CRIES-13 评分或因子分无显著差异，但初中学生的回避因子分高于高中学生。逻辑回归显示，高总 CRIES-13 评分与 MDD 以及与 COVID-19 相关的“闪回”或创伤记忆回避的经历有关。
了解 COVID-19 对中国 MDD 青少年的心理影响至关重要，尤其是女性和初中学生。需要对有精神病史的青少年进行长期监测，以进一步了解这些影响。
ChiCTR，ChiCTR2000033402，注册于 2020 年 5 月 31 日。
