Ladhani Shamez N, Ireland Georgina, Baawuah Frances, Beckmann Joanne, Okike Ifeanyichukwu O, Ahmad Shazaad, Garstang Joanna, Brent Andrew J, Brent Bernadette, Walker Jemma, Aiano Felicity, Amin-Chowdhury Zahin, Letley Louise, Flood Jessica, Jones Samuel E I, Kall Meaghan, Borrow Ray, Linley Ezra, Zambon Maria, Poh John, Lackenby Angie, Ellis Joanna, Amirthalingam Gayatri, Brown Kevin E, Ramsay Mary E
National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
Paediatric Infectious Diseases Research Group, St. George's University of London, London SW17 0RE, UK.
EClinicalMedicine. 2021 Jun 9;37:100948. doi: 10.1016/j.eclinm.2021.100948. eCollection 2021 Jul.
Older children have higher SARS-CoV-2 infection rates than younger children. We investigated SARS-CoV-2 infection, seroprevalence and seroconversion rates in staff and students following the full reopening of all secondary schools in England.
Public Health England (PHE) invited secondary schools in six regions (East and West London, Hertfordshire, Derbyshire, Manchester and Birmingham) to participate in SARS-CoV-2 surveillance during the 2020/21 academic year. Participants had nasal swabs for RT-PCR and blood samples for SARS-CoV-2 antibodies at the beginning (September 2020) and end (December 2020) of the autumn term. Multivariable logistic regression was used to assess independent risk factors for seropositivity and seroconversion.
Eighteen schools in six regions enrolled 2,209 participants, including 1,189 (53.8%) students and 1,020 (46.2%) staff. SARS-CoV-2 infection rates were not significantly different between students and staff in round one (5/948; [] vs. 2/876 [; = 0.46) or round two (10/948 [ vs. 7/886 [; = 0.63), and similar to national prevalence. None of four and 7/15 (47%) sequenced strains in rounds 1 and 2 were the highly transmissible SARS-CoV-2 B.1.1.7 variant. In round 1, antibody seropositivity was higher in students than staff (114/893 [12.8%] vs. 79/861 [9.2%]; = 0.016), but similar in round 2 (117/893 [13.1%] vs.117/872 [13.3%]; = 0.85), comparable to local community seroprevalence. Between the two rounds, 8.7% (57/652) staff and 6.6% (36/549) students seroconverted ( = 0.16).
In secondary schools, SARS-CoV-2 infection, seropositivity and seroconversion rates were similar in staff and students, and comparable to local community rates. Ongoing surveillance will be important for monitoring the impact of new variants in educational settings.
大龄儿童的新冠病毒感染率高于年幼儿童。我们调查了在英格兰所有中学全面复课后教职工和学生中的新冠病毒感染情况、血清阳性率和血清转化率。
英国公共卫生署（PHE）邀请了六个地区（东伦敦、西伦敦、赫特福德郡、德比郡、曼彻斯特和伯明翰）的中学参与2020/21学年的新冠病毒监测。参与者在秋季学期开始时（2020年9月）和结束时（2020年12月）采集鼻拭子进行逆转录聚合酶链反应（RT-PCR）检测，并采集血样检测新冠病毒抗体。采用多变量逻辑回归分析评估血清阳性和血清转化的独立危险因素。
六个地区的18所学校招募了2209名参与者，其中包括1189名（53.8%）学生和1020名（46.2%）教职工。第一轮（5/948 [ ] vs. 2/876 [ ]； = 0.46）和第二轮（10/948 [ ] vs. 7/886 [ ]； = 0.63）学生和教职工的新冠病毒感染率无显著差异，且与全国患病率相似。第一轮和第二轮测序的4株毒株及7/15（47%）株毒株中均没有高传播性的新冠病毒B.1.1.7变异株。第一轮中，学生的抗体血清阳性率高于教职工（114/893 [12.8%] vs. 79/861 [9.2%]； = 0.016），但第二轮相似（117/893 [13.1%] vs. 117/872 [13.3%]； = 0.85），与当地社区血清阳性率相当。两轮之间，8.7%（57/652）的教职工和6.6%（36/549）的学生发生了血清转化（ = 0.16）。
在中学里，教职工和学生的新冠病毒感染率、血清阳性率和血清转化率相似，且与当地社区水平相当。持续监测对于监测教育环境中新冠病毒新变异株的影响很重要。
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