Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Chuo-ku, Tokyo, Japan
Faculty of Bioscience and Applied Chemistry, Hosei University, Koganei, Tokyo, Japan.
BMJ Support Palliat Care. 2022 Mar;12(1):33-37. doi: 10.1136/bmjspcare-2021-003141. Epub 2021 Aug 13.
A strategy for maintaining and/or improving cardiorespiratory fitness (CRF) in the growing population of cancer survivors is of major clinical importance, especially in the COVID-19 era. The effect of unsupervised high-intensity interval training (HIIT) on increasing CRF in breast cancer survivors is unknown.
The purpose of this study was to determine whether the newly developed habit-B programme, which involves home-based smartphone-supported HIIT using body weight exercises, improves CRF in early-stage breast cancer survivors.
This single-centre, 12-week, parallel-group, single-blind, randomised controlled trial involved 50 women with stage I-IIa breast cancer, aged 20-59 years, who had completed initial treatment except for hormone therapy. Participants were randomised to either the exercise or control group. The primary outcome was the 12-week change in peak oxygen uptake [Formula: see text]. Other outcomes included muscle strength, 6 min walk test, resting heart rate, physical activity, fatigue, safety and quality of life.
The change in [Formula: see text] and leg strength increased significantly in the exercise group compared with the control group (p<0.01). Changes in other outcomes were not significantly different between the groups.
A home-based HIIT intervention can lead to improve CRF and muscle strength in early-stage breast cancer survivors.
对于不断增长的癌症幸存者群体，维持和/或提高心肺适能（CRF）的策略具有重要的临床意义，尤其是在 COVID-19 时代。非监督高强度间歇训练（HIIT）对提高乳腺癌幸存者 CRF 的影响尚不清楚。
本研究旨在确定新开发的习惯-B 计划是否能提高早期乳腺癌幸存者的 CRF，该计划涉及使用体重练习的基于家庭的智能手机支持的 HIIT。
这是一项单中心、12 周、平行组、单盲、随机对照试验，涉及 50 名年龄在 20-59 岁、已完成初始治疗（除激素治疗外）的 I 期-IIa 期乳腺癌女性患者。参与者被随机分配到运动组或对照组。主要结局是 12 周时峰值摄氧量[Formula: see text]的变化。其他结局包括肌肉力量、6 分钟步行试验、静息心率、身体活动、疲劳、安全性和生活质量。
与对照组相比，运动组的[Formula: see text]和腿部力量的变化显著增加（p<0.01）。两组间其他结局的变化无显著差异。
基于家庭的 HIIT 干预可以提高早期乳腺癌幸存者的 CRF 和肌肉力量。
