Jayaraman Selvaraj, Umapathy Vidhya Rekha, Govindaraj Jayamathi, Govidaraj Keerthidaa
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai,Chennai-600 100, India.
Bioinformation. 2021 Jan 31;17(1):223-228. doi: 10.6026/97320630017223. eCollection 2021.
It is known that vascular endothelial growth factor receptor (VGFR) is linked with cancer. Therefore, it is of interest to document the molecular binding features of bioactive molecules from Piper longum as potential anti-cancer agents with VGFR2 for further consideration. Thus, we document the binding features of four compounds (sesamin, fargesin, longamide and piperlonguminine) with VGFR2 for further consideration in drug discovery.
已知血管内皮生长因子受体(VGFR)与癌症有关。因此,记录来自荜茇的生物活性分子作为潜在抗癌剂与VGFR2的分子结合特征以供进一步研究很有意义。因此,我们记录了四种化合物(芝麻素、法尔格辛、荜茇酰胺和胡椒碱)与VGFR2的结合特征,以供药物研发进一步参考。