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环境毒素是骨质流失的主要原因。

Environmental Toxins Are a Major Cause of Bone Loss.

作者信息

Pizzorno Joseph, Pizzorno Lara

出版信息

Integr Med (Encinitas). 2021 Feb;20(1):10-17.

PMID:34393671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8352419/
Abstract

The environmental metals cadmium, lead, and mercury, and chemicals such as pesticides, phthalates, and bisphenols, disrupt bone metabolism in many ways. Body levels of these toxins directly correlate, in a dose-dependent manner, with risk of fracture and osteoporosis. This editorial provides a brief summary of key research showing mechanisms of damage, sources, and key strategies to decrease body load.

摘要

环境中的金属镉、铅和汞,以及农药、邻苯二甲酸盐和双酚等化学物质,会通过多种方式扰乱骨骼代谢。这些毒素在人体内的含量与骨折和骨质疏松症的风险呈剂量依赖性直接相关。这篇社论简要总结了关键研究,展示了损伤机制、来源以及降低体内毒素负荷的关键策略。

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Integr Med (Encinitas). 2021 Feb;20(1):10-17.
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本文引用的文献

1
Evidence Supporting a Phased Immuno-physiological Approach to COVID-19 From Prevention Through Recovery.支持从预防到康复对新冠病毒采用分阶段免疫生理方法的证据。
Integr Med (Encinitas). 2020;19(Suppl 1):8-35.
2
A Review on the Effects of Bisphenol A and Its Derivatives on Skeletal Health.双酚 A 及其衍生物对骨骼健康影响的综述。
Int J Med Sci. 2018 Jun 22;15(10):1043-1050. doi: 10.7150/ijms.25634. eCollection 2018.
3
Low-level lead exposure and mortality in US adults: a population-based cohort study.美国成年人低水平铅暴露与死亡率:一项基于人群的队列研究。
Lancet Public Health. 2018 Apr;3(4):e177-e184. doi: 10.1016/S2468-2667(18)30025-2. Epub 2018 Mar 12.
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Bisphenol A exposure disturbs the bone metabolism: An evolving interest towards an old culprit.双酚 A 暴露会扰乱骨代谢:一个对旧罪魁祸首的新关注。
Life Sci. 2018 Apr 1;198:1-7. doi: 10.1016/j.lfs.2018.02.013. Epub 2018 Feb 10.
5
Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis.孕妇尿液中双酚A和邻苯二甲酸酯代谢物浓度与血浆维生素D水平:一项重复测量分析
Environ Health Perspect. 2017 Aug 31;125(8):087026. doi: 10.1289/EHP1178.
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Sclerostin deficiency in humans.人类中的硬化蛋白缺乏症。
Bone. 2017 Mar;96:51-62. doi: 10.1016/j.bone.2016.10.010. Epub 2016 Oct 11.
7
Is the Diabetes Epidemic Primarily Due to Toxins?糖尿病流行主要是由毒素引起的吗?
Integr Med (Encinitas). 2016 Aug;15(4):8-17.
8
Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women.绝经后女性胫骨的骨铅(Pb)含量与胫骨远端皮质变薄和骨体积密度降低有关。
Bone. 2015 Oct;79:58-64. doi: 10.1016/j.bone.2015.05.010. Epub 2015 May 15.
9
Urinary phthalate metabolites and the risk of low bone mineral density and osteoporosis in older women.尿邻苯二甲酸代谢物与老年女性低骨密度和骨质疏松症的风险。
J Clin Endocrinol Metab. 2014 Oct;99(10):E1997-2003. doi: 10.1210/jc.2014-2279. Epub 2014 Jul 22.
10
Lead-based decorative paints: where are they still sold-and why?含铅装饰漆:它们仍在哪些地方销售——原因何在?
Environ Health Perspect. 2014 Apr;122(4):A96-A103. doi: 10.1289/ehp.122-A96.