Nayak V K, Kshirsagar N A, Desai N K, Satoskar R S
Clinical Pharmacology Unit (CDRI), Seth G. S. Medical College, Bombay, India.
Br J Clin Pharmacol. 1988 Nov;26(5):604-6. doi: 10.1111/j.1365-2125.1988.tb05302.x.
The effect of the menstrual cycle on antipyrine pharmacokinetics was studied in 11 normal, healthy Indian female volunteers. Antipyrine half-life, apparent volume of distribution, clearance and AUC were calculated by standard methods. Results indicated that in females, antipyrine half-life was significantly longer on day 5 as compared with that on days 15 and 21 of the menstrual cycle. It appears that hormonal changes during the menstrual cycle affect the pharmacokinetics of drugs in normal healthy females.
在11名正常、健康的印度女性志愿者中研究了月经周期对安替比林药代动力学的影响。通过标准方法计算安替比林的半衰期、表观分布容积、清除率和药时曲线下面积。结果表明，在女性中，月经周期第5天的安替比林半衰期明显长于第15天和第21天。看来月经周期中的激素变化会影响正常健康女性体内药物的药代动力学。
