月经周期对健康印度女性志愿者中安替比林药代动力学的影响。
Influence of menstrual cycle on antipyrine pharmacokinetics in healthy Indian female volunteers.
作者信息
Nayak V K, Kshirsagar N A, Desai N K, Satoskar R S
机构信息
Clinical Pharmacology Unit (CDRI), Seth G. S. Medical College, Bombay, India.
出版信息
Br J Clin Pharmacol. 1988 Nov;26(5):604-6. doi: 10.1111/j.1365-2125.1988.tb05302.x.
Abstract
The effect of the menstrual cycle on antipyrine pharmacokinetics was studied in 11 normal, healthy Indian female volunteers. Antipyrine half-life, apparent volume of distribution, clearance and AUC were calculated by standard methods. Results indicated that in females, antipyrine half-life was significantly longer on day 5 as compared with that on days 15 and 21 of the menstrual cycle. It appears that hormonal changes during the menstrual cycle affect the pharmacokinetics of drugs in normal healthy females.
摘要
在11名正常、健康的印度女性志愿者中研究了月经周期对安替比林药代动力学的影响。通过标准方法计算安替比林的半衰期、表观分布容积、清除率和药时曲线下面积。结果表明，在女性中，月经周期第5天的安替比林半衰期明显长于第15天和第21天。看来月经周期中的激素变化会影响正常健康女性体内药物的药代动力学。
相似文献
1
Influence of menstrual cycle on antipyrine pharmacokinetics in healthy Indian female volunteers.月经周期对健康印度女性志愿者中安替比林药代动力学的影响。
Br J Clin Pharmacol. 1988 Nov;26(5):604-6. doi: 10.1111/j.1365-2125.1988.tb05302.x.
2
Antipyrine pharmacokinetics in women receiving conjugated estrogens.
J Clin Pharmacol. 1988 May;28(5):463-6. doi: 10.1002/j.1552-4604.1988.tb05761.x.
3
Effect of short-term starvation and water deprivation on pharmacokinetics of antipyrine in calves.短期饥饿和缺水对犊牛安替比林药代动力学的影响。
Arch Vet Pol. 1992;32(3-4):119-25.
4
Pharmacokinetics of antipyrine in calves during first 35 days of life.出生后前35天犊牛中安替比林的药代动力学
Arch Vet Pol. 1992;32(1-2):75-81.
5
Disposition of antipyrine in African patients with Hodgkin's lymphoma.非洲霍奇金淋巴瘤患者中安替比林的处置情况。
Br J Clin Pharmacol. 1987 Dec;24(6):809-11. doi: 10.1111/j.1365-2125.1987.tb03249.x.
6
Effect of ciprofloxacin on the pharmacokinetics of antipyrine in healthy volunteers.
J Clin Pharm Ther. 1990 Apr;15(2):151-4. doi: 10.1111/j.1365-2710.1990.tb00370.x.
7
Antipyrine kinetics in undernourished diabetics.营养不良型糖尿病患者的安替比林动力学
Eur J Clin Pharmacol. 1991;41(4):359-61. doi: 10.1007/BF00314968.
8
Antipyrine metabolism during the menstrual cycle.月经周期中的安替比林代谢
Clin Pharmacol Ther. 1980 Sep;28(3):384-91. doi: 10.1038/clpt.1980.177.
9
Seasonal variations of antipyrine pharmacokinetics parameters in calves.犊牛中安替比林药代动力学参数的季节性变化。
Arch Vet Pol. 1992;32(1-2):67-73.
10
N-acetylation and oxidative capacity in aged volunteers determined with sulfamethazine and antipyrine.用磺胺二甲嘧啶和安替比林测定老年志愿者的N-乙酰化和氧化能力。
Int J Clin Pharmacol Ther Toxicol. 1991 Dec;29(12):469-73.
引用本文的文献
1
Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence.青春期肝脏药物代谢酶活性的激素调节
Clin Pharmacol Ther. 2008 Dec;84(6):662-73. doi: 10.1038/clpt.2008.202. Epub 2008 Oct 29.
2
Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs.月经周期中的生理变化及其对药物药代动力学和药效学的影响。
Clin Pharmacokinet. 1998 Mar;34(3):203-18. doi: 10.2165/00003088-199834030-00003.
3
[13C]Aminopyrine breath test detects altered liver metabolism caused by low-dose oral contraceptives.[13C]氨基比林呼气试验可检测低剂量口服避孕药引起的肝脏代谢改变。
Dig Dis Sci. 1995 Nov;40(11):2417-22. doi: 10.1007/BF02063247.
4
Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics.
Eur J Clin Pharmacol. 1990;39(1):59-61. doi: 10.1007/BF02657059.
本文引用的文献
1
Influence of sex difference on the pharmacological action and metabolism of some drugs.性别差异对某些药物药理作用及代谢的影响。
Biochem Pharmacol. 1962 Mar;11:221-7. doi: 10.1016/0006-2952(62)90077-1.
2
Antipyrine metabolism during the menstrual cycle.月经周期中的安替比林代谢
Clin Pharmacol Ther. 1980 Sep;28(3):384-91. doi: 10.1038/clpt.1980.177.
3
The influence of oral contraceptives on the metabolism of methaqualone in man.口服避孕药对甲喹酮在人体代谢的影响。
Br J Clin Pharmacol. 1982 Sep;14(3):341-5. doi: 10.1111/j.1365-2125.1982.tb01989.x.
4
The influence of the menstrual cycle on the metabolism and clearance of methaqualone.月经周期对甲喹酮代谢及清除率的影响。
Br J Clin Pharmacol. 1982 Sep;14(3):333-9. doi: 10.1111/j.1365-2125.1982.tb01988.x.
5
Prolongation of antipyrine half-life after correction of severe anaemia due to hookworm infestation.钩虫感染所致重度贫血纠正后安替比林半衰期延长。
Br J Clin Pharmacol. 1982 May;13(5):745-7. doi: 10.1111/j.1365-2125.1982.tb01451.x.
6
Sex differences in the pharmacokinetics of salicylates.
Eur J Clin Pharmacol. 1983;25(5):679-82. doi: 10.1007/BF00542358.
7
Influence of sex and oral contraceptive steroids on paracetamol metabolism.性别及口服避孕药类固醇对扑热息痛代谢的影响。
Br J Clin Pharmacol. 1983 Nov;16(5):503-9. doi: 10.1111/j.1365-2125.1983.tb02207.x.
8
Effect of age and sex on human drug metabolism.年龄和性别对人体药物代谢的影响。
Br Med J. 1971 Sep 11;3(5775):607-9. doi: 10.1136/bmj.3.5775.607.
9
The effects of oestrogens and progestins on the response of mice to barbiturates.雌激素和孕激素对小鼠对巴比妥类药物反应的影响。
Br J Pharmacol. 1969 Sep;37(1):129-39. doi: 10.1111/j.1476-5381.1969.tb09530.x.
10
Some alterations in the pattern of drug metabolism aociated with pegnancy, oral contraceptives, and the newly-born.一些与妊娠、口服避孕药及新生儿相关的药物代谢模式改变。
Br J Anaesth. 1966 Jun;38(6):446-54. doi: 10.1093/bja/38.6.446.
Zotero 插件